Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage: A prospective, randomised controlled trial

H. J. Lin, F. Y. Lee, W. M. Kang, Y. T. Tsai, S. D. Lee, C. H. Lee

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Abstract

We conducted a prospective randomised controlled trial of 137 patients with massive peptic ulcer haemorrhage over a period of 12 months to compare the haemostatic effects of endoscopic heat probe thermocoagulation and pure alcohol injection. Seventy eight patients (56.9%) were in shock at the time of randomisation to the trial. The age, sex, number of patients in shock, haemoglobin value at the time of entry to the trial, number of patients with severe medical illness, location of bleeders, and stigmata of recent haemorrhage were comparable among the heat probe, pure alcohol and control groups. The initial haemostatic effect of the heat probe was better than that of the pure alcohol injection (44 of 45 v 31 of 46, p = 0.0004). The ultimate haemostasis achieved by the heat probe group (41 of 45) was better than that of the pure alcohol group (31 of 46, p = 0.012) and of controls (24 of 46, p = 0.0001). The duration of hospital stay was shorter for patients in the heat probe group than for the control group (6.2 days v 13.8 days, p <0.05). The incidence of emergency surgery was less for the heat probe than the control group (three of 45 v 12 of 46, p = 0.027). The mortality rate was less in the heat probe than in the control group (one of 45 v seven of 46, p = 0.031). We suggest that heat probe thermocoagulation should be the first treatment of choice for arrest of massive peptic ulcer haemorrhage.

Original languageEnglish
Pages (from-to)753-757
Number of pages5
JournalGut
Volume31
Issue number7
Publication statusPublished - 1990
Externally publishedYes

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Peptic Ulcer Hemorrhage
Electrocoagulation
Randomized Controlled Trials
Hot Temperature
Alcohols
Injections
Control Groups
Hemostatics
Shock
Christianity
Random Allocation
Hemostasis
Length of Stay
Hemoglobins
Emergencies
Hemorrhage

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage : A prospective, randomised controlled trial. / Lin, H. J.; Lee, F. Y.; Kang, W. M.; Tsai, Y. T.; Lee, S. D.; Lee, C. H.

In: Gut, Vol. 31, No. 7, 1990, p. 753-757.

Research output: Contribution to journalArticle

Lin, H. J. ; Lee, F. Y. ; Kang, W. M. ; Tsai, Y. T. ; Lee, S. D. ; Lee, C. H. / Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage : A prospective, randomised controlled trial. In: Gut. 1990 ; Vol. 31, No. 7. pp. 753-757.
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