Heart rate variability in patients with frontal lobe epilepsy

Tomor Harnod, Cheryl C H Yang, Yue Loong Hsin, Pen Jung Wang, Kun Ruey Shieh, Terry B J Kuo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To identify autonomic dysregulation in frontal lobe epilepsy (FLE). Methods: We studied 14 male and 11 female subjects with FLE and an equal number of matched healthy control subjects. Lead I electrocardiograms were obtained for 5 min in the interictal state during daytime. Frequency-domain analysis of heart rate variability was performed and the data subsequently converted to heart rate interval and high frequency (HF; 0.15-0.45 Hz) power which representing vagal or parasympathetic regulation, as well as low frequency (LF; 0.04-0.15 Hz) power and LF/(HF + LF) expressed in normalized units (LF%) (considered to mirror sympathetic regulation). Differences in data between groups were compared using t-test. Results: The epilepsy group had a lower mean heart rate interval and a lower high frequency power. Conclusions: Patients with FLE have interictally faster heart rates, attributed to lower parasympathetic drive, which may contribute to the higher incidence of sudden death that is seen in this group of patients. This suggests that the mechanism of decreased HRV in patients with FLE is probably different from that in patients with temporal lobe epilepsy.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalSeizure
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Frontal Lobe Epilepsy
Heart Rate
Temporal Lobe Epilepsy
Sudden Death
Epilepsy
Healthy Volunteers
Electrocardiography
Incidence

Keywords

  • Autonomic
  • Epilepsy
  • Frontal
  • Heart rate variability

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R., & Kuo, T. B. J. (2009). Heart rate variability in patients with frontal lobe epilepsy. Seizure, 18(1), 21-25. https://doi.org/10.1016/j.seizure.2008.05.013

Heart rate variability in patients with frontal lobe epilepsy. / Harnod, Tomor; Yang, Cheryl C H; Hsin, Yue Loong; Wang, Pen Jung; Shieh, Kun Ruey; Kuo, Terry B J.

In: Seizure, Vol. 18, No. 1, 01.2009, p. 21-25.

Research output: Contribution to journalArticle

Harnod, T, Yang, CCH, Hsin, YL, Wang, PJ, Shieh, KR & Kuo, TBJ 2009, 'Heart rate variability in patients with frontal lobe epilepsy', Seizure, vol. 18, no. 1, pp. 21-25. https://doi.org/10.1016/j.seizure.2008.05.013
Harnod, Tomor ; Yang, Cheryl C H ; Hsin, Yue Loong ; Wang, Pen Jung ; Shieh, Kun Ruey ; Kuo, Terry B J. / Heart rate variability in patients with frontal lobe epilepsy. In: Seizure. 2009 ; Vol. 18, No. 1. pp. 21-25.
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