Abstract
Changes in heart rate variability (HRV) as a result of autonomic dysfunction has been reported in patients with epileptic seizures and this condition is associated with higher morbidity and mortality. Because most studies have been limited to cases of temporal lobe epilepsy, our study focused on cases of generalized epilepsy and examined changes in sympathetic and parasympathetic regulation. Five patients with generalized seizures were enrolled. Before seizure control and for 6 months or more after seizure control, precordial electrocardiograms were taken during an interictal period in the daytime. Frequency-domain analysis of HRV was performed using a nonparametric method of fast Fourier transformation. Each power spectrum was subsequently converted to standard frequency domain measures, including R-R interval (RR), high frequency power (HF; 0.15-0.40 Hz), low frequency power (LF; 0.04-0.15 Hz), and LF/(HF+LF) expressed in normalized units (LF%). After seizure control, there was a significant increase in HF and significant decrease in LF% relative to their levels before seizure control but no changes in RR or LF were noted. Thus, control of generalized seizures was accompanied by a simultaneous increase in parasympathetic regulation and decrease in sympathetic regulation. Our study confirms that seizure control may modulate autonomic function.
| Original language | English |
|---|---|
| Journal | Tzu Chi Medical Journal |
| Volume | 18 |
| Issue number | 5 |
| Publication status | Published - Oct 2006 |
| Externally published | Yes |
Fingerprint
Keywords
- Epilepsy
- Heart rate variability
- Parasympathetic
- Sympathetic
ASJC Scopus subject areas
- Medicine(all)
Cite this
Heart rate variability before and after seizure control in five patients with generalized seizures. / Yang, Hung Jen; Hsin, Yue Loong; Harnod, Tomor; Yang, Cheryl C H; Kuo, Terry B J.
In: Tzu Chi Medical Journal, Vol. 18, No. 5, 10.2006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heart rate variability before and after seizure control in five patients with generalized seizures
AU - Yang, Hung Jen
AU - Hsin, Yue Loong
AU - Harnod, Tomor
AU - Yang, Cheryl C H
AU - Kuo, Terry B J
PY - 2006/10
Y1 - 2006/10
N2 - Changes in heart rate variability (HRV) as a result of autonomic dysfunction has been reported in patients with epileptic seizures and this condition is associated with higher morbidity and mortality. Because most studies have been limited to cases of temporal lobe epilepsy, our study focused on cases of generalized epilepsy and examined changes in sympathetic and parasympathetic regulation. Five patients with generalized seizures were enrolled. Before seizure control and for 6 months or more after seizure control, precordial electrocardiograms were taken during an interictal period in the daytime. Frequency-domain analysis of HRV was performed using a nonparametric method of fast Fourier transformation. Each power spectrum was subsequently converted to standard frequency domain measures, including R-R interval (RR), high frequency power (HF; 0.15-0.40 Hz), low frequency power (LF; 0.04-0.15 Hz), and LF/(HF+LF) expressed in normalized units (LF%). After seizure control, there was a significant increase in HF and significant decrease in LF% relative to their levels before seizure control but no changes in RR or LF were noted. Thus, control of generalized seizures was accompanied by a simultaneous increase in parasympathetic regulation and decrease in sympathetic regulation. Our study confirms that seizure control may modulate autonomic function.
AB - Changes in heart rate variability (HRV) as a result of autonomic dysfunction has been reported in patients with epileptic seizures and this condition is associated with higher morbidity and mortality. Because most studies have been limited to cases of temporal lobe epilepsy, our study focused on cases of generalized epilepsy and examined changes in sympathetic and parasympathetic regulation. Five patients with generalized seizures were enrolled. Before seizure control and for 6 months or more after seizure control, precordial electrocardiograms were taken during an interictal period in the daytime. Frequency-domain analysis of HRV was performed using a nonparametric method of fast Fourier transformation. Each power spectrum was subsequently converted to standard frequency domain measures, including R-R interval (RR), high frequency power (HF; 0.15-0.40 Hz), low frequency power (LF; 0.04-0.15 Hz), and LF/(HF+LF) expressed in normalized units (LF%). After seizure control, there was a significant increase in HF and significant decrease in LF% relative to their levels before seizure control but no changes in RR or LF were noted. Thus, control of generalized seizures was accompanied by a simultaneous increase in parasympathetic regulation and decrease in sympathetic regulation. Our study confirms that seizure control may modulate autonomic function.
KW - Epilepsy
KW - Heart rate variability
KW - Parasympathetic
KW - Sympathetic
UR - http://www.scopus.com/inward/record.url?scp=33750924134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750924134&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33750924134
VL - 18
JO - Tzu Chi Medical Journal
JF - Tzu Chi Medical Journal
SN - 1016-3190
IS - 5
ER -