Heart failure epicardial fat increases atrial arrhythmogenesis

Yung Kuo Lin, Yao Chang Chen, Shih Lin Chang, Yenn Jiang Lin, Jenn Han Chen, Yung Hsin Yeh, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Obesity is an important risk factor for atrial fibrillation (AF) and heart failure (HF). The effects of epicardial fat on atrial electrophysiology were not clear. This study was to evaluate whether HF may modulate the effects of epicardial fat on atrial electrophysiology. Methods: Conventional microelectrodes recording was used to record the action potential in left (LA) and right (RA) atria of healthy (control) rabbits before and after application of epicardial fat from control or HF (ventricular pacing of 360-400 bpm for 4 weeks) rabbits. Adipokine profiles were checked in epicardial fat of control and HF rabbits. Results: The LA 90% of AP duration was prolonged by control epicardial fat (from 77 ± 6 to 87 ± 7 ms, p <0.05, n = 7), and by HF epicardial fat (from 78 ± 3 to 98 ± 4 ms, p <0.001, n = 9). However, control or HF epicardial fat did not change the AP morphology in RA. HF epicardial fat increased the contractility in LA (61 ± 11 vs. 35 ± 6 mg, p = 0.001), but not in RA. Control fat did not change the LA or RA contractility. Moreover, control and HF epicardial fat induced early and delayed afterdepolarizations in LA and RA, but only HF epicardial fat provoked spontaneous activity and burst firing in LA (n = 3/9, 33.3% vs. n = 0/7, 0%, n = 0/9, 0%, p <0.05). Compared to control fat, HF epicardial fat, had lower resistin, C-reactive protein and serum amyloid A, but similar interluekin-6, leptin, monocyte chemotactic protein-1, adiponectin and adipsin. Conclusions: HF epicardial fat increases atrial arrhythmogenesis, which may contribute to the higher atrial arrhythmia in obesity.

Original languageEnglish
Pages (from-to)1979-1983
Number of pages5
JournalInternational Journal of Cardiology
Volume167
Issue number5
DOIs
Publication statusPublished - Sep 1 2013

Fingerprint

Heart Failure
Fats
Electrophysiology
Rabbits
Obesity
Complement Factor D
Resistin
Serum Amyloid A Protein
Adipokines
Chemokine CCL2
Adiponectin
Microelectrodes
Leptin
Heart Atria
C-Reactive Protein
Atrial Fibrillation
Action Potentials
Cardiac Arrhythmias

Keywords

  • Adipokines
  • Atrial fibrillation
  • Epicardial fat
  • Heart failure
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Heart failure epicardial fat increases atrial arrhythmogenesis. / Lin, Yung Kuo; Chen, Yao Chang; Chang, Shih Lin; Lin, Yenn Jiang; Chen, Jenn Han; Yeh, Yung Hsin; Chen, Shih Ann; Chen, Yi Jen.

In: International Journal of Cardiology, Vol. 167, No. 5, 01.09.2013, p. 1979-1983.

Research output: Contribution to journalArticle

Lin, Yung Kuo ; Chen, Yao Chang ; Chang, Shih Lin ; Lin, Yenn Jiang ; Chen, Jenn Han ; Yeh, Yung Hsin ; Chen, Shih Ann ; Chen, Yi Jen. / Heart failure epicardial fat increases atrial arrhythmogenesis. In: International Journal of Cardiology. 2013 ; Vol. 167, No. 5. pp. 1979-1983.
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abstract = "Background: Obesity is an important risk factor for atrial fibrillation (AF) and heart failure (HF). The effects of epicardial fat on atrial electrophysiology were not clear. This study was to evaluate whether HF may modulate the effects of epicardial fat on atrial electrophysiology. Methods: Conventional microelectrodes recording was used to record the action potential in left (LA) and right (RA) atria of healthy (control) rabbits before and after application of epicardial fat from control or HF (ventricular pacing of 360-400 bpm for 4 weeks) rabbits. Adipokine profiles were checked in epicardial fat of control and HF rabbits. Results: The LA 90{\%} of AP duration was prolonged by control epicardial fat (from 77 ± 6 to 87 ± 7 ms, p <0.05, n = 7), and by HF epicardial fat (from 78 ± 3 to 98 ± 4 ms, p <0.001, n = 9). However, control or HF epicardial fat did not change the AP morphology in RA. HF epicardial fat increased the contractility in LA (61 ± 11 vs. 35 ± 6 mg, p = 0.001), but not in RA. Control fat did not change the LA or RA contractility. Moreover, control and HF epicardial fat induced early and delayed afterdepolarizations in LA and RA, but only HF epicardial fat provoked spontaneous activity and burst firing in LA (n = 3/9, 33.3{\%} vs. n = 0/7, 0{\%}, n = 0/9, 0{\%}, p <0.05). Compared to control fat, HF epicardial fat, had lower resistin, C-reactive protein and serum amyloid A, but similar interluekin-6, leptin, monocyte chemotactic protein-1, adiponectin and adipsin. Conclusions: HF epicardial fat increases atrial arrhythmogenesis, which may contribute to the higher atrial arrhythmia in obesity.",
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AU - Lin, Yung Kuo

AU - Chen, Yao Chang

AU - Chang, Shih Lin

AU - Lin, Yenn Jiang

AU - Chen, Jenn Han

AU - Yeh, Yung Hsin

AU - Chen, Shih Ann

AU - Chen, Yi Jen

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N2 - Background: Obesity is an important risk factor for atrial fibrillation (AF) and heart failure (HF). The effects of epicardial fat on atrial electrophysiology were not clear. This study was to evaluate whether HF may modulate the effects of epicardial fat on atrial electrophysiology. Methods: Conventional microelectrodes recording was used to record the action potential in left (LA) and right (RA) atria of healthy (control) rabbits before and after application of epicardial fat from control or HF (ventricular pacing of 360-400 bpm for 4 weeks) rabbits. Adipokine profiles were checked in epicardial fat of control and HF rabbits. Results: The LA 90% of AP duration was prolonged by control epicardial fat (from 77 ± 6 to 87 ± 7 ms, p <0.05, n = 7), and by HF epicardial fat (from 78 ± 3 to 98 ± 4 ms, p <0.001, n = 9). However, control or HF epicardial fat did not change the AP morphology in RA. HF epicardial fat increased the contractility in LA (61 ± 11 vs. 35 ± 6 mg, p = 0.001), but not in RA. Control fat did not change the LA or RA contractility. Moreover, control and HF epicardial fat induced early and delayed afterdepolarizations in LA and RA, but only HF epicardial fat provoked spontaneous activity and burst firing in LA (n = 3/9, 33.3% vs. n = 0/7, 0%, n = 0/9, 0%, p <0.05). Compared to control fat, HF epicardial fat, had lower resistin, C-reactive protein and serum amyloid A, but similar interluekin-6, leptin, monocyte chemotactic protein-1, adiponectin and adipsin. Conclusions: HF epicardial fat increases atrial arrhythmogenesis, which may contribute to the higher atrial arrhythmia in obesity.

AB - Background: Obesity is an important risk factor for atrial fibrillation (AF) and heart failure (HF). The effects of epicardial fat on atrial electrophysiology were not clear. This study was to evaluate whether HF may modulate the effects of epicardial fat on atrial electrophysiology. Methods: Conventional microelectrodes recording was used to record the action potential in left (LA) and right (RA) atria of healthy (control) rabbits before and after application of epicardial fat from control or HF (ventricular pacing of 360-400 bpm for 4 weeks) rabbits. Adipokine profiles were checked in epicardial fat of control and HF rabbits. Results: The LA 90% of AP duration was prolonged by control epicardial fat (from 77 ± 6 to 87 ± 7 ms, p <0.05, n = 7), and by HF epicardial fat (from 78 ± 3 to 98 ± 4 ms, p <0.001, n = 9). However, control or HF epicardial fat did not change the AP morphology in RA. HF epicardial fat increased the contractility in LA (61 ± 11 vs. 35 ± 6 mg, p = 0.001), but not in RA. Control fat did not change the LA or RA contractility. Moreover, control and HF epicardial fat induced early and delayed afterdepolarizations in LA and RA, but only HF epicardial fat provoked spontaneous activity and burst firing in LA (n = 3/9, 33.3% vs. n = 0/7, 0%, n = 0/9, 0%, p <0.05). Compared to control fat, HF epicardial fat, had lower resistin, C-reactive protein and serum amyloid A, but similar interluekin-6, leptin, monocyte chemotactic protein-1, adiponectin and adipsin. Conclusions: HF epicardial fat increases atrial arrhythmogenesis, which may contribute to the higher atrial arrhythmia in obesity.

KW - Adipokines

KW - Atrial fibrillation

KW - Epicardial fat

KW - Heart failure

KW - Obesity

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