Heart failure enhances arrhythmogenesis in pulmonary veins

Shih Lin Chang, Yao Chang Chen, Yung Hsin Yeh, Yu Jun Lai, Hung I. Yeh, Cheng I. Lin, Yung Kuo Lin, Yenn Jiang Lin, Tsu Juey Wu, Yi Kung Huang, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P

Original languageEnglish
Pages (from-to)666-674
Number of pages9
JournalClinical and Experimental Pharmacology and Physiology
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • Multi-electrode
  • Remodelling
  • Triggered activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

Cite this

Chang, S. L., Chen, Y. C., Yeh, Y. H., Lai, Y. J., Yeh, H. I., Lin, C. I., Lin, Y. K., Lin, Y. J., Wu, T. J., Huang, Y. K., Chen, S. A., & Chen, Y. J. (2011). Heart failure enhances arrhythmogenesis in pulmonary veins. Clinical and Experimental Pharmacology and Physiology, 38(10), 666-674. https://doi.org/10.1111/j.1440-1681.2011.05553.x