Abstract
1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P
| Original language | English |
|---|---|
| Pages (from-to) | 666-674 |
| Number of pages | 9 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 38 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Multi-electrode
- Remodelling
- Triggered activity
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Pharmacology
Cite this
Heart failure enhances arrhythmogenesis in pulmonary veins. / Chang, Shih Lin; Chen, Yao Chang; Yeh, Yung Hsin; Lai, Yu Jun; Yeh, Hung I.; Lin, Cheng I.; Lin, Yung Kuo; Lin, Yenn Jiang; Wu, Tsu Juey; Huang, Yi Kung; Chen, Shih Ann; Chen, Yi Jen.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 38, No. 10, 10.2011, p. 666-674.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heart failure enhances arrhythmogenesis in pulmonary veins
AU - Chang, Shih Lin
AU - Chen, Yao Chang
AU - Yeh, Yung Hsin
AU - Lai, Yu Jun
AU - Yeh, Hung I.
AU - Lin, Cheng I.
AU - Lin, Yung Kuo
AU - Lin, Yenn Jiang
AU - Wu, Tsu Juey
AU - Huang, Yi Kung
AU - Chen, Shih Ann
AU - Chen, Yi Jen
PY - 2011/10
Y1 - 2011/10
N2 - 1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P
AB - 1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P
KW - Multi-electrode
KW - Remodelling
KW - Triggered activity
UR - http://www.scopus.com/inward/record.url?scp=80053169710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053169710&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1681.2011.05553.x
DO - 10.1111/j.1440-1681.2011.05553.x
M3 - Article
VL - 38
SP - 666
EP - 674
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 10
ER -