Heart failure enhances arrhythmogenesis in pulmonary veins

Shih Lin Chang; Yao Chang Chen; Yung Hsin Yeh; Yu Jun Lai; Hung I. Yeh; Cheng I. Lin; Yung Kuo Lin; Yenn Jiang Lin; Tsu Juey Wu; Yi Kung Huang; Shih Ann Chen; Yi Jen Chen

doi:10.1111/j.1440-1681.2011.05553.x

Heart failure enhances arrhythmogenesis in pulmonary veins

Shih Lin Chang, Yao Chang Chen, Yung Hsin Yeh, Yu Jun Lai, Hung I. Yeh, Cheng I. Lin, Yung Kuo Lin, Yenn Jiang Lin, Tsu Juey Wu, Yi Kung Huang, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P

Original language	English
Pages (from-to)	666-674
Number of pages	9
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	38
Issue number	10
DOIs	https://doi.org/10.1111/j.1440-1681.2011.05553.x
Publication status	Published - Oct 2011

Keywords

Multi-electrode
Remodelling
Triggered activity

ASJC Scopus subject areas

Physiology
Physiology (medical)
Pharmacology

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Chang, S. L., Chen, Y. C., Yeh, Y. H., Lai, Y. J., Yeh, H. I., Lin, C. I., Lin, Y. K., Lin, Y. J., Wu, T. J., Huang, Y. K., Chen, S. A., & Chen, Y. J. (2011). Heart failure enhances arrhythmogenesis in pulmonary veins. Clinical and Experimental Pharmacology and Physiology, 38(10), 666-674. https://doi.org/10.1111/j.1440-1681.2011.05553.x

Heart failure enhances arrhythmogenesis in pulmonary veins. / Chang, Shih Lin; Chen, Yao Chang; Yeh, Yung Hsin; Lai, Yu Jun; Yeh, Hung I.; Lin, Cheng I.; Lin, Yung Kuo; Lin, Yenn Jiang; Wu, Tsu Juey; Huang, Yi Kung; Chen, Shih Ann; Chen, Yi Jen.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 38, No. 10, 10.2011, p. 666-674.

Research output: Contribution to journal › Article

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abstract = "1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P",

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