Abstract
1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P
Original language | English |
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Pages (from-to) | 666-674 |
Number of pages | 9 |
Journal | Clinical and Experimental Pharmacology and Physiology |
Volume | 38 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2011 |
Keywords
- Multi-electrode
- Remodelling
- Triggered activity
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Pharmacology