Health-related quality of life in children and adolescents with spinal dysraphism: Results from a Taiwanese sample

Jia Chi Wang, Chih Jou Lai, Tai-Tong Wong, Muh Lii Liang, Hsin Hung Chen, Rai Chi Chan, Tsui Fen Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: This study was designed to investigate health-related quality of life (HRQL) in children and adolescents with spinal dysraphism and to determine the differences between the myelomeningocele (MMC) and lipomyelomeningocele (LMMC) groups. Methods: Thirty-two patients (mean age, 13.2 years) with MMC and 28 patients (mean age, 11.3 years) with LMMC participated in this study. HRQL was measured using the Child Health Questionnaire-Parent Form 50 (CHQ-PF50). The CHQ-PF50 scores for the study participants were compared with those of a reference sample of healthy Taiwanese children. Outcomes for children with MMC were compared with those for children with LMMC. We also explored the relationships of the lesion level and associated medical problems with HRQL in these subjects. Results: Patients with MMC had significantly lower scores on the physical and psychosocial aspects of CHQ-PF50 than did healthy children. Patients with LMMC had lower scores on some domains but had comparable psychosocial summary scores. Significant differences were noted between the MMC and LMMC groups for all subscales and both summary scores. Children with a higher lesion level had poor physical health (r = -0.52, P < 0.001) but not poor psychosocial health. The number of associated medical problems, indicating their severity, was related to both physical (r = -0.77, P < 0.001) and psychosocial health (r = -0.57, P < 0.001). Conclusions: Children and adolescents with MMC have reduced HRQL compared with those with LMMC. Children and adolescents with more associated medical problems have the greatest risk of diminished physical and psychosocial well-being.

Original languageEnglish
Pages (from-to)1671-1679
Number of pages9
JournalChild's Nervous System
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 1 2013
Externally publishedYes

Keywords

  • Health-related quality of life
  • Lipomyelomeningocele
  • Myelomeningocele
  • Spinal dysraphism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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