HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator

Chin Hui Wu, Yi Jen Liao, An Cheng Shiau, Hsin Yu Lin, Yen Wan Hsueh Liu, Shih Ming Hsu

Research output: Contribution to journalArticle

Abstract

Applicators containing metal have been widely used in recent years when applying brachytherapy to patients with cervical cancer. However, the high dose rate (HDR) treatment-planning system (TPS) that is currently used in brachytherapy still assumes that the treatment environment constitutes a homogeneous water medium and does not include a dose correction for the metal material of the applicator. The primary purpose of this study was to evaluate the HDR 192 Ir dose distribution in cervical cancer patients when performing brachytherapy using a metal-containing applicator. Thermoluminescent dosimeter (TLD) measurements and Monte Carlo N-Particle eXtended (MCNPX) code were used to explore the doses to the rectum and bladder when using a Henschke applicator containing metal during brachytherapy. When the applicator was assumed to be present, the absolute dose difference between the TLD measurement and MCNPX simulation values was within approximately 5%. A comparison of the MCNPX simulation and TPS calculation values revealed that the TPS overestimated the International Commission of Radiation Units and Measurement (ICRU) rectum and bladder reference doses by 57.78% and 49.59%, respectively. We therefore suggest that the TPS should be modified to account for the shielding effects of the applicator to ensure the accuracy of the delivered doses.

Original languageEnglish
Article number17863
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 11 2015

Fingerprint

Brachytherapy
Metals
Rectum
Uterine Cervical Neoplasms
Urinary Bladder
Therapeutics
Radiation
Water
Radiation Dosimeters

ASJC Scopus subject areas

  • General

Cite this

HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator. / Wu, Chin Hui; Liao, Yi Jen; Shiau, An Cheng; Lin, Hsin Yu; Hsueh Liu, Yen Wan; Hsu, Shih Ming.

In: Scientific Reports, Vol. 5, 17863, 11.12.2015.

Research output: Contribution to journalArticle

Wu, Chin Hui ; Liao, Yi Jen ; Shiau, An Cheng ; Lin, Hsin Yu ; Hsueh Liu, Yen Wan ; Hsu, Shih Ming. / HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator. In: Scientific Reports. 2015 ; Vol. 5.
@article{b7fc7b1b839f435db356f5843e156047,
title = "HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator",
abstract = "Applicators containing metal have been widely used in recent years when applying brachytherapy to patients with cervical cancer. However, the high dose rate (HDR) treatment-planning system (TPS) that is currently used in brachytherapy still assumes that the treatment environment constitutes a homogeneous water medium and does not include a dose correction for the metal material of the applicator. The primary purpose of this study was to evaluate the HDR 192 Ir dose distribution in cervical cancer patients when performing brachytherapy using a metal-containing applicator. Thermoluminescent dosimeter (TLD) measurements and Monte Carlo N-Particle eXtended (MCNPX) code were used to explore the doses to the rectum and bladder when using a Henschke applicator containing metal during brachytherapy. When the applicator was assumed to be present, the absolute dose difference between the TLD measurement and MCNPX simulation values was within approximately 5{\%}. A comparison of the MCNPX simulation and TPS calculation values revealed that the TPS overestimated the International Commission of Radiation Units and Measurement (ICRU) rectum and bladder reference doses by 57.78{\%} and 49.59{\%}, respectively. We therefore suggest that the TPS should be modified to account for the shielding effects of the applicator to ensure the accuracy of the delivered doses.",
author = "Wu, {Chin Hui} and Liao, {Yi Jen} and Shiau, {An Cheng} and Lin, {Hsin Yu} and {Hsueh Liu}, {Yen Wan} and Hsu, {Shih Ming}",
year = "2015",
month = "12",
day = "11",
doi = "10.1038/srep17863",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator

AU - Wu, Chin Hui

AU - Liao, Yi Jen

AU - Shiau, An Cheng

AU - Lin, Hsin Yu

AU - Hsueh Liu, Yen Wan

AU - Hsu, Shih Ming

PY - 2015/12/11

Y1 - 2015/12/11

N2 - Applicators containing metal have been widely used in recent years when applying brachytherapy to patients with cervical cancer. However, the high dose rate (HDR) treatment-planning system (TPS) that is currently used in brachytherapy still assumes that the treatment environment constitutes a homogeneous water medium and does not include a dose correction for the metal material of the applicator. The primary purpose of this study was to evaluate the HDR 192 Ir dose distribution in cervical cancer patients when performing brachytherapy using a metal-containing applicator. Thermoluminescent dosimeter (TLD) measurements and Monte Carlo N-Particle eXtended (MCNPX) code were used to explore the doses to the rectum and bladder when using a Henschke applicator containing metal during brachytherapy. When the applicator was assumed to be present, the absolute dose difference between the TLD measurement and MCNPX simulation values was within approximately 5%. A comparison of the MCNPX simulation and TPS calculation values revealed that the TPS overestimated the International Commission of Radiation Units and Measurement (ICRU) rectum and bladder reference doses by 57.78% and 49.59%, respectively. We therefore suggest that the TPS should be modified to account for the shielding effects of the applicator to ensure the accuracy of the delivered doses.

AB - Applicators containing metal have been widely used in recent years when applying brachytherapy to patients with cervical cancer. However, the high dose rate (HDR) treatment-planning system (TPS) that is currently used in brachytherapy still assumes that the treatment environment constitutes a homogeneous water medium and does not include a dose correction for the metal material of the applicator. The primary purpose of this study was to evaluate the HDR 192 Ir dose distribution in cervical cancer patients when performing brachytherapy using a metal-containing applicator. Thermoluminescent dosimeter (TLD) measurements and Monte Carlo N-Particle eXtended (MCNPX) code were used to explore the doses to the rectum and bladder when using a Henschke applicator containing metal during brachytherapy. When the applicator was assumed to be present, the absolute dose difference between the TLD measurement and MCNPX simulation values was within approximately 5%. A comparison of the MCNPX simulation and TPS calculation values revealed that the TPS overestimated the International Commission of Radiation Units and Measurement (ICRU) rectum and bladder reference doses by 57.78% and 49.59%, respectively. We therefore suggest that the TPS should be modified to account for the shielding effects of the applicator to ensure the accuracy of the delivered doses.

UR - http://www.scopus.com/inward/record.url?scp=84949644739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949644739&partnerID=8YFLogxK

U2 - 10.1038/srep17863

DO - 10.1038/srep17863

M3 - Article

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 17863

ER -