Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

Kuo Ching Chao, Chun Chao Chang, Eddy Owaga, Chyi Huey Bai, Tzu chieh Huang, Wen Harn Pan, Jung Su Chang

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3 Citations (Scopus)

Abstract

Objective: Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents. Design: A population-based, cross-sectional study. Setting: National Nutrition and Health Survey in Taiwan (2010–2011, adolescents). Subjects: Healthy adolescents aged 13–18 years. Results: In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,

Original languageEnglish
JournalPublic Health Nutrition
Volume19
Issue number6
DOIs
Publication statusPublished - Apr 2016

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Keywords

  • Alanine aminotransferase
  • Dyslipidaemia
  • Hb
  • Liver function
  • Taiwanese adolescents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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