Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm

Ju Pin Pan, Tsai Mu Cheng, Chun Che Shih, Shu Chiung Chiang, Shiu Chin Chou, Simon J T Mao, Shiau Ting Lai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Inflammation is associated with the disruption of the aortic media and appears to play a fundamental role in the progression and development of abdominal aortic aneurysm (AAA). Haptoglobin (Hp) is a genetically determined acute phase protein, the synthesis of which is increased during inflammation. This study was designed to investigate both phenotype and plasma levels of Hp in patients with AAA. Methods: Patients with documented AAA who were admitted for elective open repair operation or endograft stent implantation, and non-AAA subjects admitted for coronary arteriography, but found to have normal or insignificant coronary artery disease, were included in the study. Plasma Hp levels were determined using a standard specific enzyme-linked immunosorbent assay, while Hp phenotype was determined by native polyacrylamide gel electrophoresis. Total cholesterol, high density lipoprotein, low density lipoprotein, and triglyceride levels were analyzed enzymatically, and C-reactive protein was analyzed by immunochemistry. Results: Forty-five patients with AAA and 49 non-AAA subjects were included. The Hp 2-2 phenotype was more predominant in AAA patients compared with non-AAA subjects, but this difference was not significant (67% vs 47%; P = .141), while plasma Hp concentrations were significantly higher in AAA patients (237 ± 144 vs 163 ± 86 ng/mL; P = .024). Further analysis revealed that plasma Hp concentrations were significantly higher in AAA patients with the 2-2 phenotype compared with corresponding non-AAA subjects (238 ± 144 vs 163 ± 86 ng/mL;P = .024). Conclusions: Our findings suggest that plasma Hp concentrations are elevated in patients with AAA, particularly those with the Hp 2-2 phenotype.

Original languageEnglish
Pages (from-to)1189-1194
Number of pages6
JournalJournal of Vascular Surgery
Volume53
Issue number5
DOIs
Publication statusPublished - May 2011
Externally publishedYes

Fingerprint

Haptoglobins
Abdominal Aortic Aneurysm
Phenotype
Aortic Aneurysm
Inflammation
Immunochemistry
Native Polyacrylamide Gel Electrophoresis
Acute-Phase Proteins
C-Reactive Protein
HDL Cholesterol
Stents
Coronary Artery Disease
Angiography
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm. / Pan, Ju Pin; Cheng, Tsai Mu; Shih, Chun Che; Chiang, Shu Chiung; Chou, Shiu Chin; Mao, Simon J T; Lai, Shiau Ting.

In: Journal of Vascular Surgery, Vol. 53, No. 5, 05.2011, p. 1189-1194.

Research output: Contribution to journalArticle

Pan, Ju Pin ; Cheng, Tsai Mu ; Shih, Chun Che ; Chiang, Shu Chiung ; Chou, Shiu Chin ; Mao, Simon J T ; Lai, Shiau Ting. / Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm. In: Journal of Vascular Surgery. 2011 ; Vol. 53, No. 5. pp. 1189-1194.
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