Handgrip strength might possibly be improved by oral vitamin d3 supplementation in older people with sarcopenia: A systematic review and meta-analysis

Tsung Han Yang, Rong Sen Yang, Chen Kun Liaw, Tai Yin Wu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background/Purpose: Supplementation with vitamin D3 has been reported to increase appendicular muscle strength. This meta-analysis reports the effects of oral vitamin D3 supplementation on sarcopenia. Methods: We conducted a systemic search of the electronic databases: PubMed, Cochrane Library and CINAHL from January 2008 to July 2020. We included clinical trials on humans. The outcome was change in handgrip strength. Results: A total of 269 studies were identified. Eight studies were included. The cumulative sample size was 1,334 patients. The majority were elderly (mean 65.2 years) and women (63.6%). The intervention period ranged from 3 to 12 months with daily doses from 100 IU to 20,000 IU per week. The total mean difference in handgrip strength change was 0.60 kg (95% confidence interval (CI):-0.78 to 1.98). In studies with daily vitamin D3 dosage over 800 IU, there was a trend of association between handgrip strength and vitamin D3 with a total mean difference of 0.62 kg (95% CI: 0.07 to 1.17). Conclusion: Oral vitamin D3 supplementation may not be effective in increasing handgrip strength among older adults. However, there was a tendency of increased handgrip strength in studies with a daily dosage of vitamin D3 over 800 IU. Dosage may play a crucial role.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalAging Medicine and Healthcare
Volume11
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • Handgrip strength
  • Meta-analysis
  • Muscle strength
  • Sarcopenia
  • Vitamin D

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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