Hairy cell leukemia: Experience of two cases in Taiwan

Li Mien Chen, Yoke Chun Chung, Tsu Yi Chao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hairy cell leukemia (HCL) is rare in the Far East. HCL is an uncommon chronic B cell lymphoproliferative disorder characterized by splenomegaly, cytopenias, and neoplastic "hairy cells" in blood, marrow, and other hematopoietic organs. Cases reported from Japan have atypical features different from cases from Western countries. Here, we report two Chinese patients with HCL, and attempt to determine whether their clinical features are more similar to those of the Western countries or to those from Japan. Both patients are middle-aged women with mild to moderate splenomegaly and cytopenias. Their hairy cells showed strong tartrate-resistant acid phosphatase (TRAP) activity and had a monoclonal B cell immunophenotype. Both patients were treated with 2-chlorodeoxyadenosine (2-CdA) and went into complete clinical and hematological remission 3 to 6 weeks after treatment. Our data, and previously published studies, confirm that 2-CdA is the most effective therapy for HCL, and should be used as the first line therapy for all patients with HCL. The Chinese cases of HCL had clinical and cytological features similar to cases from the West.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of Medical Sciences (Taiwan)
Volume25
Issue number3
Publication statusPublished - Jun 2005
Externally publishedYes

Fingerprint

Hairy Cell Leukemia
Taiwan
Cladribine
Splenomegaly
Japan
B-Lymphocytes
Far East
Lymphoproliferative Disorders
Blood Cells
Therapeutics
Bone Marrow

Keywords

  • 2-Chlorodeoxyadenosine
  • Cytopenias
  • Hairy cell leukemia
  • Splenomegaly

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hairy cell leukemia : Experience of two cases in Taiwan. / Chen, Li Mien; Chung, Yoke Chun; Chao, Tsu Yi.

In: Journal of Medical Sciences (Taiwan), Vol. 25, No. 3, 06.2005, p. 157-160.

Research output: Contribution to journalArticle

Chen, Li Mien ; Chung, Yoke Chun ; Chao, Tsu Yi. / Hairy cell leukemia : Experience of two cases in Taiwan. In: Journal of Medical Sciences (Taiwan). 2005 ; Vol. 25, No. 3. pp. 157-160.
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