Haemophilus influenzae type b combination vaccines and atopic disorders: A prospective cohort study

I. Jen Wang, Li Min Huang, Yueliang Leon Guo, Wu Shiun Hsieh, Tien-Jen Lin, Pau Chung Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Purpose: Epidemiologic evidence for an association between vaccinations and atopy development is inconsistent. We evaluated the influence of Haemophilus influenzae type b (Hib) combination vaccines in 6-month-old infants on the prevalence of atopic disorders in 18-month-old children. Methods: We used multistage, stratified systematic sampling to recruit 24,200 mother-newborn pairs from the Taiwan national birth registration in 2005. Vaccination status was ascertained through official vaccine cards, while risk factors for atopic disorders were gathered by questionnaires at 6 months of age. Information about development of atopic dermatitis (AD) and recurrent wheezing was collected at 18 months of age. The relationship between atopic disorders and Hib combination vaccines, diphtheria-pertussis-tetanus-Hib and oral poliomyelitis vaccines (DPT-Hib&OPV) and DPT-Hib-inactivated poliomyelitis vaccines (DPT-Hib-IPV), were estimated by multiple logistic regression. Results: A total of 19,968 children completed the follow-up and participated in the study. AD was noted in 1584 (7.9%) infants while recurrent wheezing was found in 1220 (6.1%) infants. The adjusted odds ratios (ORs) (95% CI) for the development of AD in the DPT-Hib&OPV and DPT-Hib-IPV vaccination groups were given as 1.38 (1.15-1.65) and 1.49 (1.29-1.72), compared to those without Hib vaccination (DTP&OPV vaccination). However, the association between DPT-Hib&OPV and DPT-Hib-IPV vaccinations and recurrent wheezing failed to reach statistical significance. Conclusion: There is a potential risk for AD after receiving Hib combination vaccines. Hib vaccination is important to the public health, and therefore the observation requires further investigations.

Original languageEnglish
Pages (from-to)711-718
Number of pages8
JournalJournal of the Formosan Medical Association
Volume111
Issue number12
DOIs
Publication statusPublished - Dec 1 2012

Keywords

  • Atopic dermatitis
  • Haemophilus influenzae type b
  • Recurrent wheezing
  • Vaccines

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Haemophilus influenzae type b combination vaccines and atopic disorders: A prospective cohort study'. Together they form a unique fingerprint.

  • Cite this