Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate.

C. H. Loh, T. S. Shih, S. H. Liou, Y. C. Lin, An-Tsz Hsieh, C. Y. Chen, G. D. Liao

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: 2-Ethoxy ethyl acetate (2-EEA) is a solvent with broad industrial and commercial applications. It has been reported to cause hematological toxicity, infertility, and teratogenesis. AIMS: To investigate the haematological effects in 2-EEA exposed workers. METHODS: Workers from one silk screening shop (n = 29), using 2-EEA as the major cleaning and printing solvent, were recruited as a high exposure group. Workers with indirect and non-exposure to 2-EEA (n = 56) were recruited as the comparison group. Venous blood was collected for blood routine examination. Air concentration of 2-EEA in this plant was measured by eight hour personal sampling. RESULTS: The geometric mean (GM) of air concentration of 2-EEA in the high exposure group was 7.41 ppm (range 1.35-16.5 pppm). The mean exposure of female workers (GM = 9.34 ppm) was significantly higher than that of male workers (GM = 4.87 ppm). The GM of air 2-EEA concentration in the comparison group was 0.07 ppm (range: non-detectable to 3.62 ppm, n = 26). The haemoglobin and haematocrit in the female high 2-EEA exposure workers were significantly lower than those of female workers in the comparison group. No difference was found between male 2-EEA high exposure and comparison group workers. The haemoglobin, haematocrit, and RBC count in the study population had a significant dose-response relation with air 2-EEA levels. CONCLUSION: Results suggest that 2-EEA is a haematological toxicant, which leads to anaemic status in high exposure female workers.

Original languageEnglish
JournalOccupational and Environmental Medicine
Volume60
Issue number9
Publication statusPublished - Sep 1 2003
Externally publishedYes

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Silk
Air
Hematocrit
Hemoglobins
ethyl acetate
Teratogenesis
Printing
Infertility

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Loh, C. H., Shih, T. S., Liou, S. H., Lin, Y. C., Hsieh, A-T., Chen, C. Y., & Liao, G. D. (2003). Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate. Occupational and Environmental Medicine, 60(9).

Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate. / Loh, C. H.; Shih, T. S.; Liou, S. H.; Lin, Y. C.; Hsieh, An-Tsz; Chen, C. Y.; Liao, G. D.

In: Occupational and Environmental Medicine, Vol. 60, No. 9, 01.09.2003.

Research output: Contribution to journalArticle

Loh, CH, Shih, TS, Liou, SH, Lin, YC, Hsieh, A-T, Chen, CY & Liao, GD 2003, 'Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate.', Occupational and Environmental Medicine, vol. 60, no. 9.
Loh, C. H. ; Shih, T. S. ; Liou, S. H. ; Lin, Y. C. ; Hsieh, An-Tsz ; Chen, C. Y. ; Liao, G. D. / Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate. In: Occupational and Environmental Medicine. 2003 ; Vol. 60, No. 9.
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