Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - Related to acetone-based organic solvent?

Jiann Keh Chen, Mai Szu Wu, Chih Wei Yang, Jeng Yi Huang, Po Yaur Hsu, Chun Liang Lin, Chiu Ching Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 55-year-old woman presented with Guillain-Barré syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na±K±Cl- cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barré syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents.

Original languageEnglish
Pages (from-to)560-565
Number of pages6
JournalAmerican Journal of Nephrology
Volume22
Issue number5-6
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Lipoid Nephrosis
Acetone
Nephrotic Syndrome
Occupational Exposure
Proton Pumps
Interstitial Nephritis
Peripheral Nervous System Diseases
Neurologic Manifestations
Extremities
Kidney
Biopsy

Keywords

  • Acetone
  • Guillain-Barré syndrome
  • Minimal change nephrotic syndrome
  • Renal tubular dysfunction

ASJC Scopus subject areas

  • Nephrology

Cite this

Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - Related to acetone-based organic solvent? / Chen, Jiann Keh; Wu, Mai Szu; Yang, Chih Wei; Huang, Jeng Yi; Hsu, Po Yaur; Lin, Chun Liang; Huang, Chiu Ching.

In: American Journal of Nephrology, Vol. 22, No. 5-6, 2002, p. 560-565.

Research output: Contribution to journalArticle

Chen, Jiann Keh ; Wu, Mai Szu ; Yang, Chih Wei ; Huang, Jeng Yi ; Hsu, Po Yaur ; Lin, Chun Liang ; Huang, Chiu Ching. / Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - Related to acetone-based organic solvent?. In: American Journal of Nephrology. 2002 ; Vol. 22, No. 5-6. pp. 560-565.
@article{1aa71a5be73c4dc183534b0bd7ece5a9,
title = "Guillain-Barr{\'e} syndrome associated with minimal change glomerulopathy and tubular dysfunction - Related to acetone-based organic solvent?",
abstract = "A 55-year-old woman presented with Guillain-Barr{\'e} syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na±K±Cl- cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barr{\'e} and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barr{\'e} syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents.",
keywords = "Acetone, Guillain-Barr{\'e} syndrome, Minimal change nephrotic syndrome, Renal tubular dysfunction",
author = "Chen, {Jiann Keh} and Wu, {Mai Szu} and Yang, {Chih Wei} and Huang, {Jeng Yi} and Hsu, {Po Yaur} and Lin, {Chun Liang} and Huang, {Chiu Ching}",
year = "2002",
doi = "10.1159/000065268",
language = "English",
volume = "22",
pages = "560--565",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "5-6",

}

TY - JOUR

T1 - Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - Related to acetone-based organic solvent?

AU - Chen, Jiann Keh

AU - Wu, Mai Szu

AU - Yang, Chih Wei

AU - Huang, Jeng Yi

AU - Hsu, Po Yaur

AU - Lin, Chun Liang

AU - Huang, Chiu Ching

PY - 2002

Y1 - 2002

N2 - A 55-year-old woman presented with Guillain-Barré syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na±K±Cl- cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barré syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents.

AB - A 55-year-old woman presented with Guillain-Barré syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na±K±Cl- cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barré syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents.

KW - Acetone

KW - Guillain-Barré syndrome

KW - Minimal change nephrotic syndrome

KW - Renal tubular dysfunction

UR - http://www.scopus.com/inward/record.url?scp=0036979994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036979994&partnerID=8YFLogxK

U2 - 10.1159/000065268

DO - 10.1159/000065268

M3 - Article

C2 - 12381959

AN - SCOPUS:0036979994

VL - 22

SP - 560

EP - 565

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 5-6

ER -