Growth trajectories and asthma/rhinitis in children: A longitudinal study in Taiwan

Yang Ching Chen, Tsan Hon Liou, Pau Chung Chen, Bor Luen Chiang, Yao Hsu Yang, Hsien Yu Fan, Yungling Leo Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Studies have reported the effect of body weight in early childhood on asthma. However, the effect of growth patterns during school age on asthma and rhinitis has yet to be explored. We sought to investigate whether various growth patterns predict incident asthma and rhinitis. We conducted a nationwide longitudinal study (Taiwan Children Health Study) in 14 Taiwanese communities. Body mass index (BMI) z-scores of 4422 children aged 6–11 years were collected annually and distinct growth trajectory classes were identified using a latent generalised mixture model. Pulmonary function and exhaled nitric oxide fraction (FeNO) levels were also measured. Whether different growth trajectory classes predict incident asthma and rhinitis at age 12, 15 and 18 years was determined using a discrete time hazard model. Four growth trajectory classes were identified. Persistently overweight children exhibited significantly increased risks of asthma and rhinitis at age 12 years. Furthermore, being persistently overweight had a long-term effect on incident asthma (hazard ratio 2.47, 95% CI 1.18–5.12) and rhinitis (hazard ratio 1.44, 95% CI 1.12–1.84) in adolescence and early adulthood. Children in high BMI classes exhibited significantly lower pulmonary functions compared with normal growth children. FeNO levels were lower in children in the high BMI classes and higher in children showing declining obesity compared with normal growth children. Persistently overweight children exhibited incident asthma and rhinitis in adolescence and early adulthood.

Original languageEnglish
Article number1600741
JournalEuropean Respiratory Journal
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Rhinitis
Taiwan
Longitudinal Studies
Asthma
Growth
Body Mass Index
Nitric Oxide
Lung
Proportional Hazards Models
Obesity
Body Weight

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Growth trajectories and asthma/rhinitis in children : A longitudinal study in Taiwan. / Chen, Yang Ching; Liou, Tsan Hon; Chen, Pau Chung; Chiang, Bor Luen; Yang, Yao Hsu; Fan, Hsien Yu; Lee, Yungling Leo.

In: European Respiratory Journal, Vol. 49, No. 1, 1600741, 01.01.2017.

Research output: Contribution to journalArticle

Chen, Yang Ching ; Liou, Tsan Hon ; Chen, Pau Chung ; Chiang, Bor Luen ; Yang, Yao Hsu ; Fan, Hsien Yu ; Lee, Yungling Leo. / Growth trajectories and asthma/rhinitis in children : A longitudinal study in Taiwan. In: European Respiratory Journal. 2017 ; Vol. 49, No. 1.
@article{18805bdde02549adb423ddf90bfa1394,
title = "Growth trajectories and asthma/rhinitis in children: A longitudinal study in Taiwan",
abstract = "Studies have reported the effect of body weight in early childhood on asthma. However, the effect of growth patterns during school age on asthma and rhinitis has yet to be explored. We sought to investigate whether various growth patterns predict incident asthma and rhinitis. We conducted a nationwide longitudinal study (Taiwan Children Health Study) in 14 Taiwanese communities. Body mass index (BMI) z-scores of 4422 children aged 6–11 years were collected annually and distinct growth trajectory classes were identified using a latent generalised mixture model. Pulmonary function and exhaled nitric oxide fraction (FeNO) levels were also measured. Whether different growth trajectory classes predict incident asthma and rhinitis at age 12, 15 and 18 years was determined using a discrete time hazard model. Four growth trajectory classes were identified. Persistently overweight children exhibited significantly increased risks of asthma and rhinitis at age 12 years. Furthermore, being persistently overweight had a long-term effect on incident asthma (hazard ratio 2.47, 95{\%} CI 1.18–5.12) and rhinitis (hazard ratio 1.44, 95{\%} CI 1.12–1.84) in adolescence and early adulthood. Children in high BMI classes exhibited significantly lower pulmonary functions compared with normal growth children. FeNO levels were lower in children in the high BMI classes and higher in children showing declining obesity compared with normal growth children. Persistently overweight children exhibited incident asthma and rhinitis in adolescence and early adulthood.",
author = "Chen, {Yang Ching} and Liou, {Tsan Hon} and Chen, {Pau Chung} and Chiang, {Bor Luen} and Yang, {Yao Hsu} and Fan, {Hsien Yu} and Lee, {Yungling Leo}",
year = "2017",
month = "1",
day = "1",
doi = "10.1183/13993003.00741-2016",
language = "English",
volume = "49",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "1",

}

TY - JOUR

T1 - Growth trajectories and asthma/rhinitis in children

T2 - A longitudinal study in Taiwan

AU - Chen, Yang Ching

AU - Liou, Tsan Hon

AU - Chen, Pau Chung

AU - Chiang, Bor Luen

AU - Yang, Yao Hsu

AU - Fan, Hsien Yu

AU - Lee, Yungling Leo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Studies have reported the effect of body weight in early childhood on asthma. However, the effect of growth patterns during school age on asthma and rhinitis has yet to be explored. We sought to investigate whether various growth patterns predict incident asthma and rhinitis. We conducted a nationwide longitudinal study (Taiwan Children Health Study) in 14 Taiwanese communities. Body mass index (BMI) z-scores of 4422 children aged 6–11 years were collected annually and distinct growth trajectory classes were identified using a latent generalised mixture model. Pulmonary function and exhaled nitric oxide fraction (FeNO) levels were also measured. Whether different growth trajectory classes predict incident asthma and rhinitis at age 12, 15 and 18 years was determined using a discrete time hazard model. Four growth trajectory classes were identified. Persistently overweight children exhibited significantly increased risks of asthma and rhinitis at age 12 years. Furthermore, being persistently overweight had a long-term effect on incident asthma (hazard ratio 2.47, 95% CI 1.18–5.12) and rhinitis (hazard ratio 1.44, 95% CI 1.12–1.84) in adolescence and early adulthood. Children in high BMI classes exhibited significantly lower pulmonary functions compared with normal growth children. FeNO levels were lower in children in the high BMI classes and higher in children showing declining obesity compared with normal growth children. Persistently overweight children exhibited incident asthma and rhinitis in adolescence and early adulthood.

AB - Studies have reported the effect of body weight in early childhood on asthma. However, the effect of growth patterns during school age on asthma and rhinitis has yet to be explored. We sought to investigate whether various growth patterns predict incident asthma and rhinitis. We conducted a nationwide longitudinal study (Taiwan Children Health Study) in 14 Taiwanese communities. Body mass index (BMI) z-scores of 4422 children aged 6–11 years were collected annually and distinct growth trajectory classes were identified using a latent generalised mixture model. Pulmonary function and exhaled nitric oxide fraction (FeNO) levels were also measured. Whether different growth trajectory classes predict incident asthma and rhinitis at age 12, 15 and 18 years was determined using a discrete time hazard model. Four growth trajectory classes were identified. Persistently overweight children exhibited significantly increased risks of asthma and rhinitis at age 12 years. Furthermore, being persistently overweight had a long-term effect on incident asthma (hazard ratio 2.47, 95% CI 1.18–5.12) and rhinitis (hazard ratio 1.44, 95% CI 1.12–1.84) in adolescence and early adulthood. Children in high BMI classes exhibited significantly lower pulmonary functions compared with normal growth children. FeNO levels were lower in children in the high BMI classes and higher in children showing declining obesity compared with normal growth children. Persistently overweight children exhibited incident asthma and rhinitis in adolescence and early adulthood.

UR - http://www.scopus.com/inward/record.url?scp=85022168147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85022168147&partnerID=8YFLogxK

U2 - 10.1183/13993003.00741-2016

DO - 10.1183/13993003.00741-2016

M3 - Article

C2 - 27824597

AN - SCOPUS:85022168147

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 1

M1 - 1600741

ER -