@article{32f99e0b35d24835ad40359b28d2719f,
title = "Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells",
abstract = "The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ ADSC (autologous transplanted 1 106 cells per rat), and DM+ ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and DM) and autologous ADSC transplantation could partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared with DM+ADSC, significant improvement in cardiac functions can be observed in DM+ADSC+E in echocardiographic data, histological observations, and even cellular protein expression. Oral green tea EGCG administration and autologous ADSC transplantation show synergistically beneficial effects on diabetic cardiac myopathy in DM rats. NEW & NOTEWORTHY Cardiomyopathy can be induced in rats with diabetes mellitus (DM). Heart function can be restored in DM rats with adipose-derived stem cell treatment. Oral epigallocatechin gallate (EGCG) administration synergistically enhances cardiac function in DM rats with stem cell treatment. The EGCG and stem cell treatment cross-effect occurs via survival protein expression.",
keywords = "Adiposederived stem cells, Diabetes mellitus, Diabetic cardiomyopathy, Green tea, Heart failure",
author = "Chen, {Tung Sheng} and Liou, {Show Yih} and Kuo, {Chia Hua} and Pan, {Lung Fa} and Yeh, {Yu Lan} and Jeffery Liou and Padma, {V. Vijaya} and Yao, {Chun Hsu} and Kuo, {Wei Wen} and Huang, {Chih Yang}",
note = "Funding Information: This study was supported in part by the Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004). Funding Information: 1Biomaterials Translational Research Center, China Medical University Hospital, Taichung, Taiwan; 2Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan; 3Formosan Blood Purification Foundation, Taipei, Taiwan; 4Department of Sports Sciences, University of Taipei, Taipei, Taiwan; 5Division of Cardiology, Armed Force Taichung General Hospital, Taichung, Taiwan; 6Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan; 7Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan; 8Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan; 9Comprehensive Weight Management Center, Taipei Medical University Hospital, Taipei, Taiwan; 10Department of Biotechnology, Bharathiar University, Coimbatore, India; 11Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; 12School of Chinese Medicine, China Medical University, Taichung, Taiwan; 13Department of Biomedical Informatics, Asia University, Taichung, Taiwan; 14Department of Biological Science and Technology, China Medical University, Taichung, Taiwan; 15Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan; 16Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; and 17Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam Publisher Copyright: {\textcopyright} 2017 the American Physiological Society.",
year = "2017",
month = nov,
day = "1",
doi = "10.1152/japplphysiol.00471.2016",
language = "English",
volume = "123",
pages = "1081--1091",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",
}
