Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells

Tung Sheng Chen, Show Yih Liou, Chia Hua Kuo, Lung Fa Pan, Yu Lan Yeh, Jeffery Liou, V. Vijaya Padma, Chun Hsu Yao, Wei Wen Kuo, Chih Yang Huang

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7 Citations (Scopus)

Abstract

The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ ADSC (autologous transplanted 1 106 cells per rat), and DM+ ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and DM) and autologous ADSC transplantation could partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared with DM+ADSC, significant improvement in cardiac functions can be observed in DM+ADSC+E in echocardiographic data, histological observations, and even cellular protein expression. Oral green tea EGCG administration and autologous ADSC transplantation show synergistically beneficial effects on diabetic cardiac myopathy in DM rats. NEW & NOTEWORTHY Cardiomyopathy can be induced in rats with diabetes mellitus (DM). Heart function can be restored in DM rats with adipose-derived stem cell treatment. Oral epigallocatechin gallate (EGCG) administration synergistically enhances cardiac function in DM rats with stem cell treatment. The EGCG and stem cell treatment cross-effect occurs via survival protein expression.

Original languageEnglish
Pages (from-to)1081-1091
Number of pages11
JournalJournal of Applied Physiology
Volume123
Issue number5
DOIs
Publication statusPublished - Nov 1 2017

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Keywords

  • Adiposederived stem cells
  • Diabetes mellitus
  • Diabetic cardiomyopathy
  • Green tea
  • Heart failure

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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