Gram-negative bacillary meningitis in adults: a recent six-year experience.

T. N. Jang, F. D. Wang, L. S. Wang, K. W. Yu, C. Y. Liu

Research output: Contribution to journalArticle

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Abstract

Thirty-eight cases of Gram-negative bacillary meningitis in adults have been identified over the past six years at the Veterans General Hospital, Taipei. Twenty cases were associated with head trauma and/or neurosurgery, while 18 cases occurred spontaneously. The overall mortality was 58%. Within the spontaneous meningitis group, 13 cases (72%) were due to Klebsiella pneumoniae, 11 cases (61%) were associated with bacteremia and eight cases (44%) with diabetes mellitus. In spite of the administration of third-generation cephalosporins, most cases of spontaneous meningitis (15 patients, 83%) died soon after diagnosis. In contrast, the clinical course for the postneurosurgical patients was more benign. Only seven patients (35%) died during the course of therapy. Common causative agents in postneurosurgical patients included Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli. External cerebrospinal fluid drainage devices were thought to be the most important predisposing factor in Gram-negative bacillary meningitis in the postneurosurgical patients. Factors that adversely influenced the mortality of Gram-negative bacillary meningitis included the presence of bacteremia, shock, deep coma and a high initial cerebrospinal fluid leukocyte count.

Original languageEnglish
Pages (from-to)540-546
Number of pages7
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume92
Issue number6
Publication statusPublished - Jun 1993
Externally publishedYes

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Meningitis
Bacteremia
Veterans Hospitals
Acinetobacter baumannii
Mortality
Klebsiella pneumoniae
Neurosurgery
Cephalosporins
Coma
Leukocyte Count
Craniocerebral Trauma
General Hospitals
Causality
Pseudomonas aeruginosa
Cerebrospinal Fluid
Shock
Diabetes Mellitus
Escherichia coli
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jang, T. N., Wang, F. D., Wang, L. S., Yu, K. W., & Liu, C. Y. (1993). Gram-negative bacillary meningitis in adults: a recent six-year experience. Journal of the Formosan Medical Association = Taiwan yi zhi, 92(6), 540-546.

Gram-negative bacillary meningitis in adults : a recent six-year experience. / Jang, T. N.; Wang, F. D.; Wang, L. S.; Yu, K. W.; Liu, C. Y.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 92, No. 6, 06.1993, p. 540-546.

Research output: Contribution to journalArticle

Jang, T. N. ; Wang, F. D. ; Wang, L. S. ; Yu, K. W. ; Liu, C. Y. / Gram-negative bacillary meningitis in adults : a recent six-year experience. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 1993 ; Vol. 92, No. 6. pp. 540-546.
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