Gout and the risk of dementia: A nationwide population-based cohort study

Jen Yee Hong, Tzuo Yun Lan, Gau Jun Tang, Chao Hsiun Tang, Tzeng Ji Chen, Hsiao Yi Lin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Introduction: Uric acid was proposed to have anti-oxidant property and possible neuroprotective effects. We examined the association between gout and dementia with population database. Methods: The study utilized the claims data from the nationwide representative sample of Taiwan National Health Insurance Research Database (NHIRD). We ascertained patients with gout and dementia covering vascular and non-vascular (including Alzheimer's) subtypes using International Classification of Diseases Ninth Revision, Clinical Modification (ICD9-CM) codes. A control group matched on sex, age, and index date of gout patients was randomly sampled with a ratio of 1:4 from the same database for comparison. Results: From 2002 to 2008, 28,769 gout patients who were older than 50 years old were identified, and 114,742 control patients was matched into the study. During follow-up, 7,119 patients developed dementia (1,214 with gout, and 5,905 without gout). After adjusting for age, sex, and relevant comorbidities, a Cox regression analysis showed that gout patients had a lower risk of developing non-vascular dementia (hazard ratio (HR): 0.77; 95% confidence interval (CI): 0.72 - 0.83; p <0.001) and vascular dementia (HR: 0.76; 95% CI: 0.65 - 0.88; p <0.001). Conclusions: Patients with gout have a lower risk of developing dementia. This phenomenon exists for both non-vascular and vascular types of dementia.

Original languageEnglish
Article number139
JournalArthritis Research and Therapy
Volume17
Issue number1
DOIs
Publication statusPublished - May 28 2015

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Gout
Dementia
Cohort Studies
Population
Vascular Dementia
Databases
Confidence Intervals
National Health Programs
Neuroprotective Agents
International Classification of Diseases
Uric Acid
Taiwan
Oxidants
Comorbidity
Regression Analysis
Control Groups
Research

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Gout and the risk of dementia : A nationwide population-based cohort study. / Hong, Jen Yee; Lan, Tzuo Yun; Tang, Gau Jun; Tang, Chao Hsiun; Chen, Tzeng Ji; Lin, Hsiao Yi.

In: Arthritis Research and Therapy, Vol. 17, No. 1, 139, 28.05.2015.

Research output: Contribution to journalArticle

Hong, Jen Yee ; Lan, Tzuo Yun ; Tang, Gau Jun ; Tang, Chao Hsiun ; Chen, Tzeng Ji ; Lin, Hsiao Yi. / Gout and the risk of dementia : A nationwide population-based cohort study. In: Arthritis Research and Therapy. 2015 ; Vol. 17, No. 1.
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