GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles

Tsung Hsien Lee, Ming Yih Wu, Hsin Fu Chen, Mei Jou Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

Abstract

The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalInternational Congress Series
Volume1271
Issue numberC
DOIs
Publication statusPublished - Sep 1 2004
Externally publishedYes

Fingerprint

Pregnancy Rate
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Nitric Oxide
Pregnancy
Embryonic Structures
Buserelin
Intracytoplasmic Sperm Injections
Serum

Keywords

  • Embryo quality
  • GnRH antagonist
  • In vitro fertilization
  • Nitric oxide
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles. / Lee, Tsung Hsien; Wu, Ming Yih; Chen, Hsin Fu; Chen, Mei Jou; Ho, Hong Nerng; Yang, Yu Shih.

In: International Congress Series, Vol. 1271, No. C, 01.09.2004, p. 93-96.

Research output: Contribution to journalArticle

Lee, Tsung Hsien ; Wu, Ming Yih ; Chen, Hsin Fu ; Chen, Mei Jou ; Ho, Hong Nerng ; Yang, Yu Shih. / GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles. In: International Congress Series. 2004 ; Vol. 1271, No. C. pp. 93-96.
@article{5b05967bc5824885b324a0e911688a94,
title = "GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles",
abstract = "The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25{\%} vs. 56.8{\%}, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.",
keywords = "Embryo quality, GnRH antagonist, In vitro fertilization, Nitric oxide, Pregnancy",
author = "Lee, {Tsung Hsien} and Wu, {Ming Yih} and Chen, {Hsin Fu} and Chen, {Mei Jou} and Ho, {Hong Nerng} and Yang, {Yu Shih}",
year = "2004",
month = "9",
day = "1",
doi = "10.1016/j.ics.2004.05.027",
language = "English",
volume = "1271",
pages = "93--96",
journal = "International Congress Series",
issn = "0531-5131",
publisher = "Elsevier BV",
number = "C",

}

TY - JOUR

T1 - GnRH antagonist protocol is associated with elevated levels of nitric oxide and a reduced pregnancy rate in IVF cycles

AU - Lee, Tsung Hsien

AU - Wu, Ming Yih

AU - Chen, Hsin Fu

AU - Chen, Mei Jou

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

PY - 2004/9/1

Y1 - 2004/9/1

N2 - The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.

AB - The study was designed to determine the nitric oxide (NO) levels in IVF/ICSI cycles subsequent to GnRH antagonist and GnRH agonist treatment and to explain the difference of pregnancy rate between these protocols. A prospective, randomized controlled study was performed with 20 patients treated with cetrorelix and 37 patients with buserelin. Serum and follicular levels of NO was determined with chemiluence method. The patients underwent the protocol with cetrorelix had less number of follicles (11.8±4.7 vs. 14.5±5.5, p=0.033) and lower pregnancy rate (25% vs. 56.8%, p=0.022), together with higher levels of serum NO (p=0.008). The follicular levels of NO were associated with fragmentation degree of embryos (p=0.030) in IVF cycles. We conclude that the GnRH antagonist protocol is associated with elevated levels of NO and a reduced pregnancy rate noted in IVF cycles. Elevated follicular levels of NO are associated with poor embryo quality.

KW - Embryo quality

KW - GnRH antagonist

KW - In vitro fertilization

KW - Nitric oxide

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85023051076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023051076&partnerID=8YFLogxK

U2 - 10.1016/j.ics.2004.05.027

DO - 10.1016/j.ics.2004.05.027

M3 - Article

AN - SCOPUS:85023051076

VL - 1271

SP - 93

EP - 96

JO - International Congress Series

JF - International Congress Series

SN - 0531-5131

IS - C

ER -