Glypican-3 Expression in Breast Cancer

Ching-Hua Tsai, Wei-Ti Su, Shyr-Ming Sheen-Chen, Jiun-Lung Liang, Hsien-Wen Hsu, Wei-Ting Chen, Eng-Yen Huang, Chao-Cheng Huang, Kung-Ming Rau, Rei-Ping Tang

Research output: Contribution to journalArticle

Abstract

Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.
Original languageEnglish
Pages (from-to)285-292
Number of pages8
Journal台灣癌症醫學雜誌
Volume2
Issue number4
DOIs
Publication statusPublished - 2015

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Glypicans
Breast Neoplasms
Tissue Array Analysis
Staining and Labeling
Tumor Biomarkers
Multivariate Analysis
Survival Rate
Survival

Keywords

  • 乳癌
  • 組織微陣列
  • glypican-3
  • breast cancer
  • tissue microarray

Cite this

Ching-Hua Tsai, Wei-Ti Su, Shyr-Ming Sheen-Chen, Jiun-Lung Liang, Hsien-Wen Hsu, Wei-Ting Chen, ... Rei-Ping Tang (2015). Glypican-3 Expression in Breast Cancer. 台灣癌症醫學雜誌, 2(4), 285-292. https://doi.org/10.6323/JCRP.2015.2.4.2

Glypican-3 Expression in Breast Cancer. / Ching-Hua Tsai; Wei-Ti Su, ; Shyr-Ming Sheen-Chen; Jiun-Lung Liang; Hsien-Wen Hsu; Wei-Ting Chen; Eng-Yen Huang; Chao-Cheng Huang; Kung-Ming Rau; Rei-Ping Tang.

In: 台灣癌症醫學雜誌, Vol. 2, No. 4, 2015, p. 285-292.

Research output: Contribution to journalArticle

Ching-Hua Tsai, Wei-Ti Su, , Shyr-Ming Sheen-Chen, Jiun-Lung Liang, Hsien-Wen Hsu, Wei-Ting Chen, Eng-Yen Huang, Chao-Cheng Huang, Kung-Ming Rau & Rei-Ping Tang 2015, 'Glypican-3 Expression in Breast Cancer', 台灣癌症醫學雜誌, vol. 2, no. 4, pp. 285-292. https://doi.org/10.6323/JCRP.2015.2.4.2
Ching-Hua Tsai, Wei-Ti Su , Shyr-Ming Sheen-Chen, Jiun-Lung Liang, Hsien-Wen Hsu, Wei-Ting Chen et al. Glypican-3 Expression in Breast Cancer. 台灣癌症醫學雜誌. 2015;2(4):285-292. https://doi.org/10.6323/JCRP.2015.2.4.2
Ching-Hua Tsai ; Wei-Ti Su, ; Shyr-Ming Sheen-Chen ; Jiun-Lung Liang ; Hsien-Wen Hsu ; Wei-Ting Chen ; Eng-Yen Huang ; Chao-Cheng Huang ; Kung-Ming Rau ; Rei-Ping Tang. / Glypican-3 Expression in Breast Cancer. In: 台灣癌症醫學雜誌. 2015 ; Vol. 2, No. 4. pp. 285-292.
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abstract = "Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.",
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AB - Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.

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