Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression

Jer An Lin, Chi Hao Wu, Chi Cheng Lu, Shih Min Hsia, Gow Chin Yen

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

In recent years, glycative stress from exogenous or endogenous advanced glycation end products (AGEs) and highly reactive dicarbonyls has gained great attention for its putative effects on cancer development. AGEs are a group of compounds formed from the complex chemical reaction of reducing sugars with compounds containing an amino group. AGEs bind to and activate the receptor for AGEs (RAGE), which is a predominant modulator of inflammation-associated cancer, and AGEs induce reactive oxygen species that are an important regulator of the hallmarks of cancer. Dicarbonyls, which are formed during glycolysis, lipid oxidation, or protein degradation, include glyoxal, methylglyoxal, and 3-deoxyglucosone and are regarded as major precursors of AGEs. These dicarbonyls not only fuel the AGE pool in living organisms but also evoke carbonyl stress, which may contribute to the carbonylative damage of carbohydrates, lipids, proteins, or DNA. Carbonylative damage then leads to many lesions, some of which are implicated in the pathogenesis of cancer. In this review, studies regarding the effects of AGEs and dicarbonyls on cancer onset or progression are systematically discussed, and the utilization of AGE inhibitors and dicarbonyl scavengers in cancer therapy are noted.

Original languageEnglish
Pages (from-to)1850-1864
Number of pages15
JournalMolecular Nutrition and Food Research
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • AGEs
  • Cancer
  • Dicarbonyls
  • RAGE
  • ROS

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Fingerprint Dive into the research topics of 'Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression'. Together they form a unique fingerprint.

  • Cite this