Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia

Yao Chun Hsu, Han Mo Chiu, Jyh Ming Liou, Chun Chao Chang, Jaw Town Lin, Hui Hsiung Liu, Ming Shiang Wu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To investigate which glycemic index is more strongly associated with colorectal neoplasia. Method: This cross-sectional study enrolled 2,776 participants in a comprehensive health management program which included measurement of fasting plasma glucose and HbA1c, along with screening colonoscopy. Primary outcome was colorectal adenoma with or without dysplasia. Risk factors for colorectal neoplasia were determined by the multivariate regression analysis, which evaluated the interrelationship among different glycemic indices in a hierarchical way. Results: Colorectal neoplasms were found in 605 (21.79%) examinees, 68 (2.45%) of whom had high-risk tumors. Glycemic indices including diagnosis of diabetes mellitus, fasting plasma glucose, and HbA1c were all associated with colorectal tumors in the univariate analysis. However, HbA1c outperformed the other two markers as an independent risk factor (adjusted odds ratio, 1.22; 95% confidence interval, 1.10-1.36%) for colorectal neoplasia. Moreover, only HbA1c remained independently associated with colorectal tumor after patients with established diagnosis of diabetes (n = 132) were excluded. We also identified age, male gender, and smoking were independent risk factors for colorectal neoplasia. Conclusion: HbA1c as compared with fasting plasma glucose is more strongly and independently associated with colorectal neoplasia. Further research is warranted to elucidate the value of HbA1c in stratifying risk of colorectal cancer.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalCancer Causes and Control
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Glycosylated Hemoglobin A
Fasting
Glycemic Index
Glucose
Colorectal Neoplasms
Neoplasms
Colonoscopy
Adenoma
Diabetes Mellitus
Multivariate Analysis
Cross-Sectional Studies
Smoking
Odds Ratio
Regression Analysis
Confidence Intervals
Health
Research

Keywords

  • Colorectal neoplasia
  • Diabetes mellitus
  • Fasting plasma glucose
  • Glycated hemoglobin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia. / Hsu, Yao Chun; Chiu, Han Mo; Liou, Jyh Ming; Chang, Chun Chao; Lin, Jaw Town; Liu, Hui Hsiung; Wu, Ming Shiang.

In: Cancer Causes and Control, Vol. 23, No. 2, 02.2012, p. 321-328.

Research output: Contribution to journalArticle

Hsu, Yao Chun ; Chiu, Han Mo ; Liou, Jyh Ming ; Chang, Chun Chao ; Lin, Jaw Town ; Liu, Hui Hsiung ; Wu, Ming Shiang. / Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 2. pp. 321-328.
@article{95d3369ebf074f4b83e9eb711c7881b2,
title = "Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia",
abstract = "Objective: To investigate which glycemic index is more strongly associated with colorectal neoplasia. Method: This cross-sectional study enrolled 2,776 participants in a comprehensive health management program which included measurement of fasting plasma glucose and HbA1c, along with screening colonoscopy. Primary outcome was colorectal adenoma with or without dysplasia. Risk factors for colorectal neoplasia were determined by the multivariate regression analysis, which evaluated the interrelationship among different glycemic indices in a hierarchical way. Results: Colorectal neoplasms were found in 605 (21.79{\%}) examinees, 68 (2.45{\%}) of whom had high-risk tumors. Glycemic indices including diagnosis of diabetes mellitus, fasting plasma glucose, and HbA1c were all associated with colorectal tumors in the univariate analysis. However, HbA1c outperformed the other two markers as an independent risk factor (adjusted odds ratio, 1.22; 95{\%} confidence interval, 1.10-1.36{\%}) for colorectal neoplasia. Moreover, only HbA1c remained independently associated with colorectal tumor after patients with established diagnosis of diabetes (n = 132) were excluded. We also identified age, male gender, and smoking were independent risk factors for colorectal neoplasia. Conclusion: HbA1c as compared with fasting plasma glucose is more strongly and independently associated with colorectal neoplasia. Further research is warranted to elucidate the value of HbA1c in stratifying risk of colorectal cancer.",
keywords = "Colorectal neoplasia, Diabetes mellitus, Fasting plasma glucose, Glycated hemoglobin",
author = "Hsu, {Yao Chun} and Chiu, {Han Mo} and Liou, {Jyh Ming} and Chang, {Chun Chao} and Lin, {Jaw Town} and Liu, {Hui Hsiung} and Wu, {Ming Shiang}",
year = "2012",
month = "2",
doi = "10.1007/s10552-011-9880-y",
language = "English",
volume = "23",
pages = "321--328",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia

AU - Hsu, Yao Chun

AU - Chiu, Han Mo

AU - Liou, Jyh Ming

AU - Chang, Chun Chao

AU - Lin, Jaw Town

AU - Liu, Hui Hsiung

AU - Wu, Ming Shiang

PY - 2012/2

Y1 - 2012/2

N2 - Objective: To investigate which glycemic index is more strongly associated with colorectal neoplasia. Method: This cross-sectional study enrolled 2,776 participants in a comprehensive health management program which included measurement of fasting plasma glucose and HbA1c, along with screening colonoscopy. Primary outcome was colorectal adenoma with or without dysplasia. Risk factors for colorectal neoplasia were determined by the multivariate regression analysis, which evaluated the interrelationship among different glycemic indices in a hierarchical way. Results: Colorectal neoplasms were found in 605 (21.79%) examinees, 68 (2.45%) of whom had high-risk tumors. Glycemic indices including diagnosis of diabetes mellitus, fasting plasma glucose, and HbA1c were all associated with colorectal tumors in the univariate analysis. However, HbA1c outperformed the other two markers as an independent risk factor (adjusted odds ratio, 1.22; 95% confidence interval, 1.10-1.36%) for colorectal neoplasia. Moreover, only HbA1c remained independently associated with colorectal tumor after patients with established diagnosis of diabetes (n = 132) were excluded. We also identified age, male gender, and smoking were independent risk factors for colorectal neoplasia. Conclusion: HbA1c as compared with fasting plasma glucose is more strongly and independently associated with colorectal neoplasia. Further research is warranted to elucidate the value of HbA1c in stratifying risk of colorectal cancer.

AB - Objective: To investigate which glycemic index is more strongly associated with colorectal neoplasia. Method: This cross-sectional study enrolled 2,776 participants in a comprehensive health management program which included measurement of fasting plasma glucose and HbA1c, along with screening colonoscopy. Primary outcome was colorectal adenoma with or without dysplasia. Risk factors for colorectal neoplasia were determined by the multivariate regression analysis, which evaluated the interrelationship among different glycemic indices in a hierarchical way. Results: Colorectal neoplasms were found in 605 (21.79%) examinees, 68 (2.45%) of whom had high-risk tumors. Glycemic indices including diagnosis of diabetes mellitus, fasting plasma glucose, and HbA1c were all associated with colorectal tumors in the univariate analysis. However, HbA1c outperformed the other two markers as an independent risk factor (adjusted odds ratio, 1.22; 95% confidence interval, 1.10-1.36%) for colorectal neoplasia. Moreover, only HbA1c remained independently associated with colorectal tumor after patients with established diagnosis of diabetes (n = 132) were excluded. We also identified age, male gender, and smoking were independent risk factors for colorectal neoplasia. Conclusion: HbA1c as compared with fasting plasma glucose is more strongly and independently associated with colorectal neoplasia. Further research is warranted to elucidate the value of HbA1c in stratifying risk of colorectal cancer.

KW - Colorectal neoplasia

KW - Diabetes mellitus

KW - Fasting plasma glucose

KW - Glycated hemoglobin

UR - http://www.scopus.com/inward/record.url?scp=84856727650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856727650&partnerID=8YFLogxK

U2 - 10.1007/s10552-011-9880-y

DO - 10.1007/s10552-011-9880-y

M3 - Article

C2 - 22124615

AN - SCOPUS:84856727650

VL - 23

SP - 321

EP - 328

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 2

ER -