Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer

Mu Kuan Chen, Hsiu Ting Tsai, Tsung Te Chung, Shih Chi Su, Te Yu Kao, Hsien Chun Tseng, Te Hsiung Liu, Hui Ling Chiou, Shun Fa Yang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background. The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk. Methods. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients. Results. Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes. Conclusions. The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.

Original languageEnglish
Pages (from-to)1079-1087
Number of pages9
JournalHead and Neck
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Fingerprint

Mouth Neoplasms
Alleles
Genes
Homozygote
Neoplasms
Confidence Intervals
Glutathione Transferase
Restriction Fragment Length Polymorphisms
glutathione S-transferase alpha
Polymerase Chain Reaction

Keywords

  • GST
  • Oral cancer
  • Polymorphism

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer. / Chen, Mu Kuan; Tsai, Hsiu Ting; Chung, Tsung Te; Su, Shih Chi; Kao, Te Yu; Tseng, Hsien Chun; Liu, Te Hsiung; Chiou, Hui Ling; Yang, Shun Fa.

In: Head and Neck, Vol. 32, No. 8, 08.2010, p. 1079-1087.

Research output: Contribution to journalArticle

Chen, MK, Tsai, HT, Chung, TT, Su, SC, Kao, TY, Tseng, HC, Liu, TH, Chiou, HL & Yang, SF 2010, 'Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer', Head and Neck, vol. 32, no. 8, pp. 1079-1087. https://doi.org/10.1002/hed.21297
Chen, Mu Kuan ; Tsai, Hsiu Ting ; Chung, Tsung Te ; Su, Shih Chi ; Kao, Te Yu ; Tseng, Hsien Chun ; Liu, Te Hsiung ; Chiou, Hui Ling ; Yang, Shun Fa. / Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer. In: Head and Neck. 2010 ; Vol. 32, No. 8. pp. 1079-1087.
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