Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity

Ming Tsan Lin, Sung Pao Kung, Sung Ling Yeh, Kuong Yi Liaw, Ming Yang Wang, Ming Liang Kuo, Po Houng Lee, Wei Jao Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II≤6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered.

Original languageEnglish
Pages (from-to)6197-6201
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number39
Publication statusPublished - Oct 21 2005

Fingerprint

alanylglutamine
Total Parenteral Nutrition
Glutamine
Interleukin-6
Nitrogen
Interleukin-8
APACHE
Dipeptides
Interferons
Interleukin-2
Parenteral Nutrition Solutions
Amino Acids
Cytokines
Control Groups

Keywords

  • Abdominal surgery
  • Glutamine
  • Interleukin-6
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lin, M. T., Kung, S. P., Yeh, S. L., Liaw, K. Y., Wang, M. Y., Kuo, M. L., ... Chen, W. J. (2005). Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World Journal of Gastroenterology, 11(39), 6197-6201.

Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. / Lin, Ming Tsan; Kung, Sung Pao; Yeh, Sung Ling; Liaw, Kuong Yi; Wang, Ming Yang; Kuo, Ming Liang; Lee, Po Houng; Chen, Wei Jao.

In: World Journal of Gastroenterology, Vol. 11, No. 39, 21.10.2005, p. 6197-6201.

Research output: Contribution to journalArticle

Lin, MT, Kung, SP, Yeh, SL, Liaw, KY, Wang, MY, Kuo, ML, Lee, PH & Chen, WJ 2005, 'Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity', World Journal of Gastroenterology, vol. 11, no. 39, pp. 6197-6201.
Lin, Ming Tsan ; Kung, Sung Pao ; Yeh, Sung Ling ; Liaw, Kuong Yi ; Wang, Ming Yang ; Kuo, Ming Liang ; Lee, Po Houng ; Chen, Wei Jao. / Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 39. pp. 6197-6201.
@article{87fef654c5c5410a9bde4be66e8b112e,
title = "Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity",
abstract = "Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II≤6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered.",
keywords = "Abdominal surgery, Glutamine, Interleukin-6, Total parenteral nutrition",
author = "Lin, {Ming Tsan} and Kung, {Sung Pao} and Yeh, {Sung Ling} and Liaw, {Kuong Yi} and Wang, {Ming Yang} and Kuo, {Ming Liang} and Lee, {Po Houng} and Chen, {Wei Jao}",
year = "2005",
month = "10",
day = "21",
language = "English",
volume = "11",
pages = "6197--6201",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "39",

}

TY - JOUR

T1 - Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity

AU - Lin, Ming Tsan

AU - Kung, Sung Pao

AU - Yeh, Sung Ling

AU - Liaw, Kuong Yi

AU - Wang, Ming Yang

AU - Kuo, Ming Liang

AU - Lee, Po Houng

AU - Chen, Wei Jao

PY - 2005/10/21

Y1 - 2005/10/21

N2 - Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II≤6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered.

AB - Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II≤6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered.

KW - Abdominal surgery

KW - Glutamine

KW - Interleukin-6

KW - Total parenteral nutrition

UR - http://www.scopus.com/inward/record.url?scp=30644469266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30644469266&partnerID=8YFLogxK

M3 - Article

C2 - 16273650

AN - SCOPUS:30644469266

VL - 11

SP - 6197

EP - 6201

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 39

ER -