補充麩醯胺對敗血症小鼠肝臟發炎反應及氧化壓力之影響

Translated title of the contribution: Glutamine Modulates Liver Inflammation And Oxidative Stress in Septic Mice

陳姿秀, 王貝文, 黃亭潔, 吳尚鴻, 葉秋莉

Research output: Contribution to journalArticle

Abstract

This study investigated the effect of intravenous glutamine (GLN) supplementation on the liver's inflammatory response and oxidative stress in a mouse model of polymicrobial sepsis. Mice were randomly assigned to a normal control (NC) group and two sepsis groups. Sepsis was induced by cecal ligation and puncture (CLP). One hour after CLP, septic mice were given saline (SS) or 0.75 g GLN/kg of body weight (SG) once via a tail vein. Septic mice were sacrificed at 24 or 48 h after CLP, and the livers were harvested for further analysis. Results showed that sepsis resulted in higher myeloperoxidase (MPO) activity and malondialdehyde (MDA) production. Interleukin (IU-1, IL-6, and tumor necrosis factor (TNF)-α levels in the liver were upregulated, whereas IL-10 and transforming growth factor (TGF)-β had decreased at 24 and/or 48 h after CLP. Compared to the SS group, the SG group had lower concentrations of IL-1, IL-6, and TNF-α and higher IL-10 and TGF-β levels. Also, MPO activity and MDA concentrations were reduced in liver tissues. These results suggest that sepsis results in inflammation of liver tissues. A single dose of intravenous GLN administration after CLP reduced oxidative stress and attenuated the inflammatory response in livers of mice with polymicrobial sepsis.
Translated title of the contributionGlutamine Modulates Liver Inflammation And Oxidative Stress in Septic Mice
Original languageTraditional Chinese
Pages (from-to)113-121
Number of pages9
JournalJournal of the Chinese Nutrition Society
Volume40
Issue number3
Publication statusPublished - Sep 1 2015
Externally publishedYes

Keywords

  • sepsis
  • glutamine
  • liver
  • proinflammatory cytokine
  • oxidative stress

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