Glutamate Concentration in the Medial Prefrontal Cortex Predicts Resting-State Cortical-Subcortical Functional Connectivity in Humans

Niall W. Duncan, Christine Wiebking, Brice Tiret, Malgoranza Marjańska, Dave J. Hayes, Oliver Lyttleton, Julien Doyon, Georg Northoff

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex - specifically the medial prefrontal cortex (mPFC) - and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.

Original languageEnglish
Article numbere60312
JournalPLoS One
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 3 2013
Externally publishedYes

Fingerprint

Prefrontal Cortex
glutamates
Glutamic Acid
Periaqueductal Gray
thalamus
Thalamus
animal communication
Communication
Animals
Nucleus Accumbens
Biochemical Phenomena
Individuality
Psychiatry
prefrontal cortex
Schizophrenia
animals
cortex
Magnetic Resonance Imaging
Psychology
Experiments

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Glutamate Concentration in the Medial Prefrontal Cortex Predicts Resting-State Cortical-Subcortical Functional Connectivity in Humans. / Duncan, Niall W.; Wiebking, Christine; Tiret, Brice; Marjańska, Malgoranza; Hayes, Dave J.; Lyttleton, Oliver; Doyon, Julien; Northoff, Georg.

In: PLoS One, Vol. 8, No. 4, e60312, 03.04.2013.

Research output: Contribution to journalArticle

Duncan, Niall W. ; Wiebking, Christine ; Tiret, Brice ; Marjańska, Malgoranza ; Hayes, Dave J. ; Lyttleton, Oliver ; Doyon, Julien ; Northoff, Georg. / Glutamate Concentration in the Medial Prefrontal Cortex Predicts Resting-State Cortical-Subcortical Functional Connectivity in Humans. In: PLoS One. 2013 ; Vol. 8, No. 4.
@article{a99150e6f7534d63b07fa47ab3f52cf5,
title = "Glutamate Concentration in the Medial Prefrontal Cortex Predicts Resting-State Cortical-Subcortical Functional Connectivity in Humans",
abstract = "Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex - specifically the medial prefrontal cortex (mPFC) - and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.",
author = "Duncan, {Niall W.} and Christine Wiebking and Brice Tiret and Malgoranza Marjańska and Hayes, {Dave J.} and Oliver Lyttleton and Julien Doyon and Georg Northoff",
year = "2013",
month = "4",
day = "3",
doi = "10.1371/journal.pone.0060312",
language = "English",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Glutamate Concentration in the Medial Prefrontal Cortex Predicts Resting-State Cortical-Subcortical Functional Connectivity in Humans

AU - Duncan, Niall W.

AU - Wiebking, Christine

AU - Tiret, Brice

AU - Marjańska, Malgoranza

AU - Hayes, Dave J.

AU - Lyttleton, Oliver

AU - Doyon, Julien

AU - Northoff, Georg

PY - 2013/4/3

Y1 - 2013/4/3

N2 - Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex - specifically the medial prefrontal cortex (mPFC) - and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.

AB - Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex - specifically the medial prefrontal cortex (mPFC) - and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=84875694533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875694533&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0060312

DO - 10.1371/journal.pone.0060312

M3 - Article

C2 - 23573246

AN - SCOPUS:84875694533

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e60312

ER -