Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

Chia Jung Liao; Tzu I. Wu; Ya Hui Huang; Ting Chang Chang; Chia Siu Wang; Ming Ming Tsai; Chyong Huey Lai; Ying Liang; Shih Ming Jung; Kwang Huei Lin

doi:10.1111/j.1349-7006.2011.02102.x

Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

Chia Jung Liao, Tzu I. Wu, Ya Hui Huang, Ting Chang Chang, Chia Siu Wang, Ming Ming Tsai, Chyong Huey Lai, Ying Liang, Shih Ming Jung, Kwang Huei Lin

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P

Original language	English
Pages (from-to)	2255-2263
Number of pages	9
Journal	Cancer Science
Volume	102
Issue number	12
DOIs	https://doi.org/10.1111/j.1349-7006.2011.02102.x
Publication status	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2011.02102.x

Cite this

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title = "Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer",

abstract = "Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P",

author = "Liao, {Chia Jung} and Wu, {Tzu I.} and Huang, {Ya Hui} and Chang, {Ting Chang} and Wang, {Chia Siu} and Tsai, {Ming Ming} and Lai, {Chyong Huey} and Ying Liang and Jung, {Shih Ming} and Lin, {Kwang Huei}",

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AU - Liao, Chia Jung

AU - Wu, Tzu I.

AU - Huang, Ya Hui

AU - Chang, Ting Chang

AU - Wang, Chia Siu

AU - Tsai, Ming Ming

AU - Lai, Chyong Huey

AU - Liang, Ying

AU - Jung, Shih Ming

AU - Lin, Kwang Huei

PY - 2011/12

Y1 - 2011/12

N2 - Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P

AB - Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P

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Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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