Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer

Chia Jung Liao, Tzu I. Wu, Ya Hui Huang, Ting Chang Chang, Chia Siu Wang, Ming Ming Tsai, Chyong Huey Lai, Ying Liang, Shih Ming Jung, Kwang Huei Lin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Human papilloma virus infection is critical but not sufficient to cause cervical cancer. Molecular markers of cervical carcinogenesis are essential. The aim of this study was to identify aberrantly expressed proteins in cervical cancer and determine their clinical significance. A two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomic strategy was used for screening candidate proteins. Immunoblotting and immunohistochemical (IHC) analyses were performed to confirm the results of 2-DE, and the clinical significance was estimated. Glucose-regulated protein58 (Grp58) was overexpressed in 73% of cancers. The IHC staining showed that the Grp58 histoscore was significantly higher in patients with adenocarcinoma (AD) compared with squamous cell carcinoma (P

Original languageEnglish
Pages (from-to)2255-2263
Number of pages9
JournalCancer Science
Volume102
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Liao, C. J., Wu, T. I., Huang, Y. H., Chang, T. C., Wang, C. S., Tsai, M. M., Lai, C. H., Liang, Y., Jung, S. M., & Lin, K. H. (2011). Glucose-regulated protein58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer. Cancer Science, 102(12), 2255-2263. https://doi.org/10.1111/j.1349-7006.2011.02102.x