Abstract

BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.

OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.

METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.

RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).

CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

Original languageEnglish
Pages (from-to)e108938
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 2014

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glaucoma
Parkinson disease
Alzheimer disease
Glaucoma
Alzheimer Disease
Population
Parkinson Disease
Confidence Intervals
confidence interval
Propensity Score
Open Angle Glaucoma
Primary Open Angle Glaucoma
Parkinson Disease 8
Low Tension Glaucoma
Incidence
Hazards
Blindness
incidence
blindness

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Glaucoma, Alzheimer's disease, and Parkinson's disease : an 8-year population-based follow-up study. / Lin, I-Chan; Wang, Yuan-Hung; Wang, Tsung-Jen; Wang, I. Jong; Shen, Yun Den; Chi, Nai-Fang; Chien, Li-Nien.

In: PLoS One, Vol. 9, No. 9, 2014, p. e108938.

Research output: Contribution to journalArticle

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title = "Glaucoma, Alzheimer's disease, and Parkinson's disease: an 8-year population-based follow-up study",
abstract = "BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95{\%} CI: 2.19-3.70) and 1.98 (95{\%} CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95{\%} CI: 3.52-5.39) and 4.37 (95{\%} CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.",
author = "I-Chan Lin and Yuan-Hung Wang and Tsung-Jen Wang and Wang, {I. Jong} and Shen, {Yun Den} and Nai-Fang Chi and Li-Nien Chien",
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TY - JOUR

T1 - Glaucoma, Alzheimer's disease, and Parkinson's disease

T2 - an 8-year population-based follow-up study

AU - Lin, I-Chan

AU - Wang, Yuan-Hung

AU - Wang, Tsung-Jen

AU - Wang, I. Jong

AU - Shen, Yun Den

AU - Chi, Nai-Fang

AU - Chien, Li-Nien

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

AB - BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

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DO - 10.1371/journal.pone.0108938

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JF - PLoS One

SN - 1932-6203

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