Ginkgo biloba treatment increases copulation but not nNOS activity in the medial preoptic area in male rats

Kuei Ying Yeh, Ching Hsiang Wu, Yuan Feen Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) on copulation in male rats following EGb 761 treatment. Adult male rats were treated with 50 mg/kg of EGb 761 or distilled water by oral gavage for 14 consecutive days. The animals were sacrificed approximately 14 h after the last behavioral test and MPOA brain tissues were collected for nNOS immunohistochemistry. EGb 761 treatment for 14 days significantly increased the intromission frequency compared to the vehicle-treated controls on day 14. An increase in ejaculation frequency was also seen in the EGb 761-treated group compared to the vehicle-treated controls on day 14 and to the same group on day 0. However, EGb 761 treatment did not influence the number of nNOS-immunoreactive cells in the MPOA. These results suggest that enhanced male copulatory performance in sexually experienced rats administered EGb 761 may not be related to central nNOS activity in the MPOA.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalNeuroscience Letters
Volume500
Issue number3
DOIs
Publication statusPublished - Aug 18 2011
Externally publishedYes

Fingerprint

Copulation
Ginkgo biloba
Nitric Oxide Synthase Type I
Preoptic Area
Therapeutics
Ejaculation
Ginkgo biloba extract 761
Nitric Oxide
Central Nervous System
Immunohistochemistry
Water
Brain

Keywords

  • Copulation
  • EGb 761
  • Medial preoptic area
  • NNOS

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ginkgo biloba treatment increases copulation but not nNOS activity in the medial preoptic area in male rats. / Yeh, Kuei Ying; Wu, Ching Hsiang; Tsai, Yuan Feen.

In: Neuroscience Letters, Vol. 500, No. 3, 18.08.2011, p. 182-186.

Research output: Contribution to journalArticle

@article{6f7f35f2c19144fe857b9d73276e4f20,
title = "Ginkgo biloba treatment increases copulation but not nNOS activity in the medial preoptic area in male rats",
abstract = "Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) on copulation in male rats following EGb 761 treatment. Adult male rats were treated with 50 mg/kg of EGb 761 or distilled water by oral gavage for 14 consecutive days. The animals were sacrificed approximately 14 h after the last behavioral test and MPOA brain tissues were collected for nNOS immunohistochemistry. EGb 761 treatment for 14 days significantly increased the intromission frequency compared to the vehicle-treated controls on day 14. An increase in ejaculation frequency was also seen in the EGb 761-treated group compared to the vehicle-treated controls on day 14 and to the same group on day 0. However, EGb 761 treatment did not influence the number of nNOS-immunoreactive cells in the MPOA. These results suggest that enhanced male copulatory performance in sexually experienced rats administered EGb 761 may not be related to central nNOS activity in the MPOA.",
keywords = "Copulation, EGb 761, Medial preoptic area, NNOS",
author = "Yeh, {Kuei Ying} and Wu, {Ching Hsiang} and Tsai, {Yuan Feen}",
year = "2011",
month = "8",
day = "18",
doi = "10.1016/j.neulet.2011.06.028",
language = "English",
volume = "500",
pages = "182--186",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Ginkgo biloba treatment increases copulation but not nNOS activity in the medial preoptic area in male rats

AU - Yeh, Kuei Ying

AU - Wu, Ching Hsiang

AU - Tsai, Yuan Feen

PY - 2011/8/18

Y1 - 2011/8/18

N2 - Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) on copulation in male rats following EGb 761 treatment. Adult male rats were treated with 50 mg/kg of EGb 761 or distilled water by oral gavage for 14 consecutive days. The animals were sacrificed approximately 14 h after the last behavioral test and MPOA brain tissues were collected for nNOS immunohistochemistry. EGb 761 treatment for 14 days significantly increased the intromission frequency compared to the vehicle-treated controls on day 14. An increase in ejaculation frequency was also seen in the EGb 761-treated group compared to the vehicle-treated controls on day 14 and to the same group on day 0. However, EGb 761 treatment did not influence the number of nNOS-immunoreactive cells in the MPOA. These results suggest that enhanced male copulatory performance in sexually experienced rats administered EGb 761 may not be related to central nNOS activity in the MPOA.

AB - Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) on copulation in male rats following EGb 761 treatment. Adult male rats were treated with 50 mg/kg of EGb 761 or distilled water by oral gavage for 14 consecutive days. The animals were sacrificed approximately 14 h after the last behavioral test and MPOA brain tissues were collected for nNOS immunohistochemistry. EGb 761 treatment for 14 days significantly increased the intromission frequency compared to the vehicle-treated controls on day 14. An increase in ejaculation frequency was also seen in the EGb 761-treated group compared to the vehicle-treated controls on day 14 and to the same group on day 0. However, EGb 761 treatment did not influence the number of nNOS-immunoreactive cells in the MPOA. These results suggest that enhanced male copulatory performance in sexually experienced rats administered EGb 761 may not be related to central nNOS activity in the MPOA.

KW - Copulation

KW - EGb 761

KW - Medial preoptic area

KW - NNOS

UR - http://www.scopus.com/inward/record.url?scp=79960647937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960647937&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2011.06.028

DO - 10.1016/j.neulet.2011.06.028

M3 - Article

VL - 500

SP - 182

EP - 186

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -