Germinoma involving the basal ganglia in children

Tai-Tong Wong, Y. W. Chen, Wan Yuo Guo, Kai Ping Chang, Donald M. Ho, Sang Hue Yen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Germinoma originating in the basal ganglia is rare, and the majority of reported papers have been from Japan. In a collection of the first 500 cases of primary brain tumors in children in Taipei Veterans General Hospital, six pure germinomas with tissue diagnosis situated in this location. Materials and methods: We reviewed the clinical features, neuroimaging studies, tumor markers, management, and outcome of these six patients. Results: All of them were boys. The median age of onset of symptoms was 9.7 years. They uniformly presented with hemiparesis. The average duration of symptoms before surgical management was 1 year. One patient had bilateral basal ganglia tumors. Serum β-human chorionic gonadotropin levels was elevated (128 mIU/ml) in one patient. Longitudinal neuroimaging studies in four patients clearly showed that the tumor arose as a tiny lesion at the lenticular nucleus. Five patients had cysts within tumors. Five patients received partial, subtotal, to total resection. One patient had stereotactic biopsy of the tumors. Postoperative primary adjuvant therapies included radiotherapy, chemotherapy alone, and combined chemotherapy and radiotherapy. Five patients survived, and one patient died of radiation-induced sarcoma with median follow-up period of 13.7 years. Local recurrence was observed in all of three patients after solitary postoperative chemotherapy. Conclusions: The lenticular nucleus is a significant locus for germinomas and can be bilateral. Although rarely reported in Western countries, it does exist in Taiwan as well. Treatment of germinomas in this specific location is similar to germinoma in other intracranial locations.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalChild's Nervous System
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 2008
Externally publishedYes

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Germinoma
Basal Ganglia
Corpus Striatum
Neuroimaging
Drug Therapy
Neoplasms
Radiotherapy
Veterans Hospitals
Paresis
Chorionic Gonadotropin
Tumor Biomarkers
Taiwan
Age of Onset
Brain Neoplasms
General Hospitals
Sarcoma
Longitudinal Studies
Cysts
Japan

Keywords

  • Basal ganglia
  • Children
  • Germinoma
  • Intracranial

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Wong, T-T., Chen, Y. W., Guo, W. Y., Chang, K. P., Ho, D. M., & Yen, S. H. (2008). Germinoma involving the basal ganglia in children. Child's Nervous System, 24(1), 71-78. https://doi.org/10.1007/s00381-007-0495-2

Germinoma involving the basal ganglia in children. / Wong, Tai-Tong; Chen, Y. W.; Guo, Wan Yuo; Chang, Kai Ping; Ho, Donald M.; Yen, Sang Hue.

In: Child's Nervous System, Vol. 24, No. 1, 01.01.2008, p. 71-78.

Research output: Contribution to journalArticle

Wong, T-T, Chen, YW, Guo, WY, Chang, KP, Ho, DM & Yen, SH 2008, 'Germinoma involving the basal ganglia in children', Child's Nervous System, vol. 24, no. 1, pp. 71-78. https://doi.org/10.1007/s00381-007-0495-2
Wong, Tai-Tong ; Chen, Y. W. ; Guo, Wan Yuo ; Chang, Kai Ping ; Ho, Donald M. ; Yen, Sang Hue. / Germinoma involving the basal ganglia in children. In: Child's Nervous System. 2008 ; Vol. 24, No. 1. pp. 71-78.
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