Genuine motorische Phänomene bei schizophrenen Psychosen: Neuronale Korrelate und Pathomechanismen

Translated title of the contribution: Genuine motor phenomena in schizophrenia: Neuronal correlates and pathomechanisms

D. Hirjak, Georg Northoff, P. A. Thomann, K. M. Kubera, R. C. Wolf

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Despite a growing body of evidence on motor dysfunction in schizophrenia spectrum disorders, the neuronal correlates of genuine motor abnormalities (GMA) are not fully elucidated at present. Moreover, the clinical relevance of a potential “motor intermediate phenotype” remains controversial. This systematic review aims at characterizing a “motor intermediate phenotype” in schizophrenia spectrum disorders. The second goal of this systematic review is to discuss GMA-associated brain alterations as potential biomarkers of psychosis risk syndrome and manifest motor symptoms against the background of current neuroimaging evidence. The detailed clinical assessment of GMA in the context of multimodal imaging could, in the future promote the early recognition of psychotic disorders and the initiation of disorder-oriented and individualized treatment. Taken as a whole the data provide initial evidence that motor dysfunction in schizophrenic spectrum disorders must be considered dimensionally. The predictive value of neurobiological results with respect to the transition to a life-threatening catatonia or the development of chronic dyskinesia, cannot currently be conclusively assessed.

Original languageGerman
Pages (from-to)27-43
Number of pages17
JournalNervenarzt
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

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Keywords

  • Classification
  • Diagnosis
  • Magnetic resonance imaging
  • Motor intermediate Phenotype
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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