Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding

Chin Lin Perng, Hwai Jeng Lin, Wen Ching Lo, Guan Ying Tseng, I. Chen Sun, Yueh Hsing Ou

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aim: Helicobacter pyloti causes chronic gastritis, peptic ulcer, gastric cancer and MALT-lymphoma. Different genotypes of Helicobacter pylori are confirmed from diverse geographic areas. Its association with bleeding peptic ulcer remains controversial. The aim of this study was to investigate the Helicobacter pylori vacA alleles, cagA and iceA in patients with bleeding peptic ulcer. Methods: We enrolled patients with bleeding, non-bleeding peptic ulcers and chronic gastritis. Biopsy specimens were obtained from the antrum of the stomach for rapid urease test, bacterial culture and PCR assay. DNA extraction and polymerase chain reaction were used to detect the presence or absence of cagA and to assess the polymorphism of vacA and iceA. Results: A total of 168 patients (60.4%) (25 patients with chronic gastritis, 26 patients with bleeding gastric ulcer, 51 patients with non-bleeding gastric ulcer, 26 patients with bleeding duodenal ulcer, and 40 patients with non-bleeding duodenal ulcer) were found to have positive PCR results between January 2001 and December 2002. Concerning genotypes, we found cagA (139/278, 50%), vacA s1a (127/278, 45.7%), and iceA1 (125/278, 45%) predominated in all studied patients. In patients with bleeding peptic ulcers, vacA s1a and m1T were fewer than those in patients with non-bleeding peptic ulcers (37/106 vs69/135, P=0.017, and 4/106 vs 21/135, P=0.002). Conclusion: In patients with peptic ulcers, H pylori vacA s1a and m1T prevent bleeding complication.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalWorld Journal of Gastroenterology
Volume10
Issue number4
Publication statusPublished - Feb 15 2004
Externally publishedYes

Fingerprint

Peptic Ulcer
Helicobacter pylori
Genotype
Hemorrhage
Gastritis
Stomach Ulcer
Duodenal Ulcer
Polymerase Chain Reaction
Helicobacter
Marginal Zone B-Cell Lymphoma
Urease
Pylorus
DNA-Directed DNA Polymerase
Stomach Neoplasms
Stomach
Alleles
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Perng, C. L., Lin, H. J., Lo, W. C., Tseng, G. Y., Sun, I. C., & Ou, Y. H. (2004). Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding. World Journal of Gastroenterology, 10(4), 602-605.

Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding. / Perng, Chin Lin; Lin, Hwai Jeng; Lo, Wen Ching; Tseng, Guan Ying; Sun, I. Chen; Ou, Yueh Hsing.

In: World Journal of Gastroenterology, Vol. 10, No. 4, 15.02.2004, p. 602-605.

Research output: Contribution to journalArticle

Perng, CL, Lin, HJ, Lo, WC, Tseng, GY, Sun, IC & Ou, YH 2004, 'Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding', World Journal of Gastroenterology, vol. 10, no. 4, pp. 602-605.
Perng, Chin Lin ; Lin, Hwai Jeng ; Lo, Wen Ching ; Tseng, Guan Ying ; Sun, I. Chen ; Ou, Yueh Hsing. / Genotypes of Helicobacter pylori in patients with peptic ulcer bleeding. In: World Journal of Gastroenterology. 2004 ; Vol. 10, No. 4. pp. 602-605.
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