Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene

Yi Ming A. Chen, Li Ying Chen, Fen Hwa Wong, Cheng Ming Lee, Tai Jay Chang, Teresa L. Yang-Feng

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S- adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. Previously, we reported that the expression level of GNMT was diminished in human hepatocellular carcinoma. In this study, the human GNMT gene was cloned and characterized. It contains six exons and spans about 10 kb. Instead of a TATA box, it has a transcriptional initiator located 801 bp upstream from the translation start codon. The gene was localized to chromosome 6p12 using fluorescence in situ hybridization. Northern blot analysis of 16 tissues from different human organs showed that GNMT was expressed only in liver, pancreas, and prostate. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalGenomics
Volume66
Issue number1
DOIs
Publication statusPublished - May 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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