Abstract
The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine SNPs including rs7081076, rs2281939, rs3818540, rs2274490, rs61739184, rs726176, rs2296966, rs17849148, and rs3193970 were genotyped and examined. To deal with correlated data of subjects within the same families, the generalized estimating equations approach was applied throughout all association analyses. The GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test. These two SNPs revealed independent associations with age of diabetes onset as well as risk of diabetes at baseline. These findings supported that SORBS1 gene participates in the pathogenesis of diabetes.
| Original language | English |
|---|---|
| Article number | 10574 |
| Journal | Scientific Reports |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1 2018 |
Fingerprint
ASJC Scopus subject areas
- General
Cite this
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes : A SAPPHIRe Cohort Study. / Chang, Tien Jyun; Wang, Wen Chang; Hsiung, Chao A.; He, Chih Tsueng; Lin, Ming Wei; Sheu, Wayne Huey Herng; Chang, Yi Cheng; Quertermous, Tom; Chen, Yii Der Ida; Rotter, Jerome I.; Chuang, Lee Ming; Hwu, Chii Min; Hung, Yi Jen; Lee, Wen Jane; Lee, I. Te.
In: Scientific Reports, Vol. 8, No. 1, 10574, 01.12.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes
T2 - A SAPPHIRe Cohort Study
AU - Chang, Tien Jyun
AU - Wang, Wen Chang
AU - Hsiung, Chao A.
AU - He, Chih Tsueng
AU - Lin, Ming Wei
AU - Sheu, Wayne Huey Herng
AU - Chang, Yi Cheng
AU - Quertermous, Tom
AU - Chen, Yii Der Ida
AU - Rotter, Jerome I.
AU - Chuang, Lee Ming
AU - Hwu, Chii Min
AU - Hung, Yi Jen
AU - Lee, Wen Jane
AU - Lee, I. Te
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine SNPs including rs7081076, rs2281939, rs3818540, rs2274490, rs61739184, rs726176, rs2296966, rs17849148, and rs3193970 were genotyped and examined. To deal with correlated data of subjects within the same families, the generalized estimating equations approach was applied throughout all association analyses. The GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test. These two SNPs revealed independent associations with age of diabetes onset as well as risk of diabetes at baseline. These findings supported that SORBS1 gene participates in the pathogenesis of diabetes.
AB - The SORBS1 gene plays an important role in insulin signaling. We aimed to examine whether common single-nucleotide polymorphisms (SNPs) of SORBS1 are associated with prevalence and incidence of diabetes, age at onset of diabetes, and the related traits of glucose homeostasis. A total of 1135 siblings from 492 ethnic Chinese families were recruited at baseline, and 630 were followed up for 5.19 ± 0.96 years. Nine SNPs including rs7081076, rs2281939, rs3818540, rs2274490, rs61739184, rs726176, rs2296966, rs17849148, and rs3193970 were genotyped and examined. To deal with correlated data of subjects within the same families, the generalized estimating equations approach was applied throughout all association analyses. The GG genotype of rs2281939 was associated with a higher risk of diabetes at baseline, an earlier onset of diabetes, and higher steady-state plasma glucose levels in the modified insulin suppression test. The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test. These two SNPs revealed independent associations with age of diabetes onset as well as risk of diabetes at baseline. These findings supported that SORBS1 gene participates in the pathogenesis of diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85049920842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049920842&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-28891-z
DO - 10.1038/s41598-018-28891-z
M3 - Article
AN - SCOPUS:85049920842
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 10574
ER -