Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population

Pei Song Gao, Rasika A. Mathias, Beverly Plunkett, Alkis Togias, Kathleen C. Barnes, Terri H. Beaty, Shau Ku Huang

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

Original languageEnglish
Pages (from-to)982-988
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume115
Issue number5
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

Fingerprint

Mucin-3
Mucin-1
African Americans
Immunoglobulins
Asthma
T-Lymphocytes
Population
Genes
Single Nucleotide Polymorphism
Hepatitis A virus
Odds Ratio
Haplotypes
Mucins
Exons

Keywords

  • Asthma
  • Haplotype
  • Hepatitis A
  • Single nucleotide polymorphism
  • T-cell immunoglobulin mucin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. / Gao, Pei Song; Mathias, Rasika A.; Plunkett, Beverly; Togias, Alkis; Barnes, Kathleen C.; Beaty, Terri H.; Huang, Shau Ku.

In: Journal of Allergy and Clinical Immunology, Vol. 115, No. 5, 01.01.2005, p. 982-988.

Research output: Contribution to journalArticle

Gao, Pei Song ; Mathias, Rasika A. ; Plunkett, Beverly ; Togias, Alkis ; Barnes, Kathleen C. ; Beaty, Terri H. ; Huang, Shau Ku. / Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. In: Journal of Allergy and Clinical Immunology. 2005 ; Vol. 115, No. 5. pp. 982-988.
@article{b09fdeccc551479eace884fbd5d7af69,
title = "Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population",
abstract = "Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.",
keywords = "Asthma, Haplotype, Hepatitis A, Single nucleotide polymorphism, T-cell immunoglobulin mucin",
author = "Gao, {Pei Song} and Mathias, {Rasika A.} and Beverly Plunkett and Alkis Togias and Barnes, {Kathleen C.} and Beaty, {Terri H.} and Huang, {Shau Ku}",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/j.jaci.2005.01.035",
language = "English",
volume = "115",
pages = "982--988",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population

AU - Gao, Pei Song

AU - Mathias, Rasika A.

AU - Plunkett, Beverly

AU - Togias, Alkis

AU - Barnes, Kathleen C.

AU - Beaty, Terri H.

AU - Huang, Shau Ku

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

AB - Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

KW - Asthma

KW - Haplotype

KW - Hepatitis A

KW - Single nucleotide polymorphism

KW - T-cell immunoglobulin mucin

UR - http://www.scopus.com/inward/record.url?scp=18144366600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144366600&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2005.01.035

DO - 10.1016/j.jaci.2005.01.035

M3 - Article

C2 - 15867855

AN - SCOPUS:18144366600

VL - 115

SP - 982

EP - 988

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -