Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort

Yah Huei Wu-Chou, Ying Ting Chen, Tu Hsueh Yeh, Hsiu Chen Chang, Yi Hsin Weng, Szu Chia Lai, Chia Ling Huang, Rou Shayn Chen, Ying Zu Huang, Chiung Chu Chen, June Hung, Wen Li Chuang, Wey Yil Lin, Chien Hsiun Chen, Chin Song Lu

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Abstract

Background: Parkinson's disease (PD) is one of the most prevalent age-related neurodegenerative diseases and usually refers to a complex disorder with multiple genetic and environmental factors influencing disease risk. We here performed a gene-based case-control association study to scrutinize whether genetic variants in SNCA and LRRK2 genes could predispose to sporadic, late-onset form of PD in Taiwanese population. Methods: 17 Single Nucleotide Polymorphisms (SNPs) markers located within SNCA gene as well as the 16 SNP markers within LRRK2 gene were chosen for genotyping and evaluated their haplotype structure in a cohort of sporadic PD patients and control individuals. Results: This study showed that two SNPs near the promoter region (rs2301134 and rs2301135) of SNCA gene gave the greatest evidence for an association with PD (p ≤ 0.01) and a haplotype block with two SNPs in the 3' UTR (rs356221 and rs11931074) revealed another evidence of association (p ≤ 0.02). For the LRRK2 gene, only R1628P variants of total 16 SNPs giving a marginal significant association with PD across the whole gene (p = 0.0058) and no haplotype block was constructed. Many genetic variants (A419V, I1122V, R1441C, R1441G, R1441H, Y1699C, M1869. V, M1869T, I2012T, G2019S, and I2020T) from previous reports were not detected in our cohort. Conclusions: We have replicated a population-based PD association study in a collection of 626 cases and 473 control subjects and confirm that genetic variants of both SNCA and LRRK2 genes are associated with susceptibility to sporadic PD but in a different distribution.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalParkinsonism and Related Disorders
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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Keywords

  • Genetic susceptibility
  • LRRK2
  • Parkinson's disease
  • Replication study
  • SNCA

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Wu-Chou, Y. H., Chen, Y. T., Yeh, T. H., Chang, H. C., Weng, Y. H., Lai, S. C., Huang, C. L., Chen, R. S., Huang, Y. Z., Chen, C. C., Hung, J., Chuang, W. L., Lin, W. Y., Chen, C. H., & Lu, C. S. (2013). Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort. Parkinsonism and Related Disorders, 19(2), 251-255. https://doi.org/10.1016/j.parkreldis.2012.10.019