Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

Ying Ju Lin, Jeng Sheng Chang, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Wen Kuei Chien, Jin Hua Chen, Jer Yuarn Wu, Chien Hsiun Chen, Li Ching Chang, Cheng Wen Lin, Tsung Jung Ho, Fuu Jen Tsai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results: We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76). Conclusions: We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.

Original languageEnglish
Article number67
JournalCell and Bioscience
Volume4
Issue number1
DOIs
Publication statusPublished - Nov 19 2014

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Coronary Aneurysm
Mucocutaneous Lymph Node Syndrome
Glutamate Receptors
Coronary Vessels
Genes
Ionotropic Glutamate Receptors
Kainic Acid
Fever
Intravenous Immunoglobulins
Odds Ratio
Genetic Association Studies
Systemic Vasculitis
Pediatrics
Polymorphism
Genetic Markers
Regression analysis
Multivariate Analysis
Regression Analysis

Keywords

  • CAA
  • GRIK1
  • KD
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms. / Lin, Ying Ju; Chang, Jeng Sheng; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chiu Chu; Huang, Shao Mei; Chien, Wen Kuei; Chen, Jin Hua; Wu, Jer Yuarn; Chen, Chien Hsiun; Chang, Li Ching; Lin, Cheng Wen; Ho, Tsung Jung; Tsai, Fuu Jen.

In: Cell and Bioscience, Vol. 4, No. 1, 67, 19.11.2014.

Research output: Contribution to journalArticle

Lin, YJ, Chang, JS, Liu, X, Tsang, H, Lin, TH, Liao, CC, Huang, SM, Chien, WK, Chen, JH, Wu, JY, Chen, CH, Chang, LC, Lin, CW, Ho, TJ & Tsai, FJ 2014, 'Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms', Cell and Bioscience, vol. 4, no. 1, 67. https://doi.org/10.1186/2045-3701-4-67
Lin, Ying Ju ; Chang, Jeng Sheng ; Liu, Xiang ; Tsang, Hsinyi ; Lin, Ting Hsu ; Liao, Chiu Chu ; Huang, Shao Mei ; Chien, Wen Kuei ; Chen, Jin Hua ; Wu, Jer Yuarn ; Chen, Chien Hsiun ; Chang, Li Ching ; Lin, Cheng Wen ; Ho, Tsung Jung ; Tsai, Fuu Jen. / Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms. In: Cell and Bioscience. 2014 ; Vol. 4, No. 1.
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abstract = "Background: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results: We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95{\%} CI =1.22-3.65; for rs425507: odds ratio =2.16; 95{\%} CI =1.26-3.76; for rs388700: odds ratio =2.16; 95{\%} CI =1.26-3.76). Conclusions: We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.",
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AU - Lin, Ying Ju

AU - Chang, Jeng Sheng

AU - Liu, Xiang

AU - Tsang, Hsinyi

AU - Lin, Ting Hsu

AU - Liao, Chiu Chu

AU - Huang, Shao Mei

AU - Chien, Wen Kuei

AU - Chen, Jin Hua

AU - Wu, Jer Yuarn

AU - Chen, Chien Hsiun

AU - Chang, Li Ching

AU - Lin, Cheng Wen

AU - Ho, Tsung Jung

AU - Tsai, Fuu Jen

PY - 2014/11/19

Y1 - 2014/11/19

N2 - Background: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results: We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76). Conclusions: We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.

AB - Background: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results: We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76). Conclusions: We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.

KW - CAA

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KW - Single nucleotide polymorphism

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