Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

Ying Ju Lin, Jeng Sheng Chang, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Wen Kuei Chien, Jin Hua Chen, Jer Yuarn Wu, Chien Hsiun Chen, Li Ching Chang, Cheng Wen Lin, Tsung Jung Ho, Fuu Jen Tsai

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4 Citations (Scopus)

Abstract

Background: Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results: We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76). Conclusions: We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.

Original languageEnglish
Article number67
JournalCell and Bioscience
Volume4
Issue number1
DOIs
Publication statusPublished - Nov 19 2014

Keywords

  • CAA
  • GRIK1
  • KD
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lin, Y. J., Chang, J. S., Liu, X., Tsang, H., Lin, T. H., Liao, C. C., Huang, S. M., Chien, W. K., Chen, J. H., Wu, J. Y., Chen, C. H., Chang, L. C., Lin, C. W., Ho, T. J., & Tsai, F. J. (2014). Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms. Cell and Bioscience, 4(1), [67]. https://doi.org/10.1186/2045-3701-4-67