Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

H. Dean Hosgood, Wen Chang Wang, Yun Chul Hong, Jiu Cun Wang, Kexin Chen, I. Shou Chang, Chien Jen Chen, Daru Lu, Zhihua Yin, Chen Wu, Wei Zheng, Biyun Qian, Jae Yong Park, Yeul Hong Kim, Nilanjan Chatterjee, Ying Chen, Gee Chen Chang, Chin Fu Hsiao, Meredith Yeager, Ying Huang TsaiHu Wei, Young Tae Kim, Wei Wu, Zhenhong Zhao, Wong Ho Chow, Xiaoling Zhu, Yen Li Lo, Sook Whan Sung, Kuan Yu Chen, Jeff Yuenger, Joo Hyun Kim, Liming Huang, Ying Hsiang Chen, Yu Tang Gao, Jin Hee Kim, Ming Shyan Huang, Tae Hoon Jung, Neil Caporaso, Xueying Zhao, Zhang Huan, Dianke Yu, Chang Ho Kim, Wu Chou Su, Xiao Ou Shu, In San Kim, Bryan Bassig, Yuh Min Chen, Sung Ick Cha, Wen Tan, Hongyan Chen, Tsung Ying Yang, Jae Sook Sung, Chih Liang Wang, Xuelian Li, Kyong Hwa Park, Chong Jen Yu, Jeong Seon Ryu, Yongbing Xiang, Amy Hutchinson, Jun Suk Kim, Qiuyin Cai, Maria Teresa Landi, Kyoung Mu Lee, Jen Yu Hung, Ju Yeon Park, Margaret Tucker, Chien Chung Lin, Yangwu Ren, Reury Perng Perng, Chih Yi Chen, Li Jin, Kun Chieh Chen, Yao Jen Li, Yu Fang Chiu, Fang Yu Tsai, Pan Chyr Yang, Joseph F. Fraumeni, Adeline Seow, Dongxin Lin, Baosen Zhou, Stephen Chanock, Chao Agnes Hsiung, Nathaniel Rothman, Qing Lan

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10 -12); however, this association did not achieve genome-wide significance (p ≠10 -7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10 -8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalHuman Genetics
Volume131
Issue number7
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes

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Smoking
Republic of Korea
Genome-Wide Association Study
Lung Neoplasms
Confidence Intervals
Singapore
Tobacco Use
Taiwan
Single Nucleotide Polymorphism
Adenocarcinoma of lung
Squamous Cell Carcinoma
China
Japan
Chromosomes
Genome
Lung

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. / Hosgood, H. Dean; Wang, Wen Chang; Hong, Yun Chul; Wang, Jiu Cun; Chen, Kexin; Chang, I. Shou; Chen, Chien Jen; Lu, Daru; Yin, Zhihua; Wu, Chen; Zheng, Wei; Qian, Biyun; Park, Jae Yong; Kim, Yeul Hong; Chatterjee, Nilanjan; Chen, Ying; Chang, Gee Chen; Hsiao, Chin Fu; Yeager, Meredith; Tsai, Ying Huang; Wei, Hu; Kim, Young Tae; Wu, Wei; Zhao, Zhenhong; Chow, Wong Ho; Zhu, Xiaoling; Lo, Yen Li; Sung, Sook Whan; Chen, Kuan Yu; Yuenger, Jeff; Kim, Joo Hyun; Huang, Liming; Chen, Ying Hsiang; Gao, Yu Tang; Kim, Jin Hee; Huang, Ming Shyan; Jung, Tae Hoon; Caporaso, Neil; Zhao, Xueying; Huan, Zhang; Yu, Dianke; Kim, Chang Ho; Su, Wu Chou; Shu, Xiao Ou; Kim, In San; Bassig, Bryan; Chen, Yuh Min; Cha, Sung Ick; Tan, Wen; Chen, Hongyan; Yang, Tsung Ying; Sung, Jae Sook; Wang, Chih Liang; Li, Xuelian; Park, Kyong Hwa; Yu, Chong Jen; Ryu, Jeong Seon; Xiang, Yongbing; Hutchinson, Amy; Kim, Jun Suk; Cai, Qiuyin; Landi, Maria Teresa; Lee, Kyoung Mu; Hung, Jen Yu; Park, Ju Yeon; Tucker, Margaret; Lin, Chien Chung; Ren, Yangwu; Perng, Reury Perng; Chen, Chih Yi; Jin, Li; Chen, Kun Chieh; Li, Yao Jen; Chiu, Yu Fang; Tsai, Fang Yu; Yang, Pan Chyr; Fraumeni, Joseph F.; Seow, Adeline; Lin, Dongxin; Zhou, Baosen; Chanock, Stephen; Hsiung, Chao Agnes; Rothman, Nathaniel; Lan, Qing.

In: Human Genetics, Vol. 131, No. 7, 07.2012, p. 1197-1203.

Research output: Contribution to journalArticle

Hosgood, HD, Wang, WC, Hong, YC, Wang, JC, Chen, K, Chang, IS, Chen, CJ, Lu, D, Yin, Z, Wu, C, Zheng, W, Qian, B, Park, JY, Kim, YH, Chatterjee, N, Chen, Y, Chang, GC, Hsiao, CF, Yeager, M, Tsai, YH, Wei, H, Kim, YT, Wu, W, Zhao, Z, Chow, WH, Zhu, X, Lo, YL, Sung, SW, Chen, KY, Yuenger, J, Kim, JH, Huang, L, Chen, YH, Gao, YT, Kim, JH, Huang, MS, Jung, TH, Caporaso, N, Zhao, X, Huan, Z, Yu, D, Kim, CH, Su, WC, Shu, XO, Kim, IS, Bassig, B, Chen, YM, Cha, SI, Tan, W, Chen, H, Yang, TY, Sung, JS, Wang, CL, Li, X, Park, KH, Yu, CJ, Ryu, JS, Xiang, Y, Hutchinson, A, Kim, JS, Cai, Q, Landi, MT, Lee, KM, Hung, JY, Park, JY, Tucker, M, Lin, CC, Ren, Y, Perng, RP, Chen, CY, Jin, L, Chen, KC, Li, YJ, Chiu, YF, Tsai, FY, Yang, PC, Fraumeni, JF, Seow, A, Lin, D, Zhou, B, Chanock, S, Hsiung, CA, Rothman, N & Lan, Q 2012, 'Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia', Human Genetics, vol. 131, no. 7, pp. 1197-1203. https://doi.org/10.1007/s00439-012-1144-8
Hosgood, H. Dean ; Wang, Wen Chang ; Hong, Yun Chul ; Wang, Jiu Cun ; Chen, Kexin ; Chang, I. Shou ; Chen, Chien Jen ; Lu, Daru ; Yin, Zhihua ; Wu, Chen ; Zheng, Wei ; Qian, Biyun ; Park, Jae Yong ; Kim, Yeul Hong ; Chatterjee, Nilanjan ; Chen, Ying ; Chang, Gee Chen ; Hsiao, Chin Fu ; Yeager, Meredith ; Tsai, Ying Huang ; Wei, Hu ; Kim, Young Tae ; Wu, Wei ; Zhao, Zhenhong ; Chow, Wong Ho ; Zhu, Xiaoling ; Lo, Yen Li ; Sung, Sook Whan ; Chen, Kuan Yu ; Yuenger, Jeff ; Kim, Joo Hyun ; Huang, Liming ; Chen, Ying Hsiang ; Gao, Yu Tang ; Kim, Jin Hee ; Huang, Ming Shyan ; Jung, Tae Hoon ; Caporaso, Neil ; Zhao, Xueying ; Huan, Zhang ; Yu, Dianke ; Kim, Chang Ho ; Su, Wu Chou ; Shu, Xiao Ou ; Kim, In San ; Bassig, Bryan ; Chen, Yuh Min ; Cha, Sung Ick ; Tan, Wen ; Chen, Hongyan ; Yang, Tsung Ying ; Sung, Jae Sook ; Wang, Chih Liang ; Li, Xuelian ; Park, Kyong Hwa ; Yu, Chong Jen ; Ryu, Jeong Seon ; Xiang, Yongbing ; Hutchinson, Amy ; Kim, Jun Suk ; Cai, Qiuyin ; Landi, Maria Teresa ; Lee, Kyoung Mu ; Hung, Jen Yu ; Park, Ju Yeon ; Tucker, Margaret ; Lin, Chien Chung ; Ren, Yangwu ; Perng, Reury Perng ; Chen, Chih Yi ; Jin, Li ; Chen, Kun Chieh ; Li, Yao Jen ; Chiu, Yu Fang ; Tsai, Fang Yu ; Yang, Pan Chyr ; Fraumeni, Joseph F. ; Seow, Adeline ; Lin, Dongxin ; Zhou, Baosen ; Chanock, Stephen ; Hsiung, Chao Agnes ; Rothman, Nathaniel ; Lan, Qing. / Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. In: Human Genetics. 2012 ; Vol. 131, No. 7. pp. 1197-1203.
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title = "Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia",
abstract = "A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10 -12); however, this association did not achieve genome-wide significance (p {\^a}‰ 10 -7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10 -8; allelic risk = 0.80, 95{\%} confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95{\%} CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.",
author = "Hosgood, {H. Dean} and Wang, {Wen Chang} and Hong, {Yun Chul} and Wang, {Jiu Cun} and Kexin Chen and Chang, {I. Shou} and Chen, {Chien Jen} and Daru Lu and Zhihua Yin and Chen Wu and Wei Zheng and Biyun Qian and Park, {Jae Yong} and Kim, {Yeul Hong} and Nilanjan Chatterjee and Ying Chen and Chang, {Gee Chen} and Hsiao, {Chin Fu} and Meredith Yeager and Tsai, {Ying Huang} and Hu Wei and Kim, {Young Tae} and Wei Wu and Zhenhong Zhao and Chow, {Wong Ho} and Xiaoling Zhu and Lo, {Yen Li} and Sung, {Sook Whan} and Chen, {Kuan Yu} and Jeff Yuenger and Kim, {Joo Hyun} and Liming Huang and Chen, {Ying Hsiang} and Gao, {Yu Tang} and Kim, {Jin Hee} and Huang, {Ming Shyan} and Jung, {Tae Hoon} and Neil Caporaso and Xueying Zhao and Zhang Huan and Dianke Yu and Kim, {Chang Ho} and Su, {Wu Chou} and Shu, {Xiao Ou} and Kim, {In San} and Bryan Bassig and Chen, {Yuh Min} and Cha, {Sung Ick} and Wen Tan and Hongyan Chen and Yang, {Tsung Ying} and Sung, {Jae Sook} and Wang, {Chih Liang} and Xuelian Li and Park, {Kyong Hwa} and Yu, {Chong Jen} and Ryu, {Jeong Seon} and Yongbing Xiang and Amy Hutchinson and Kim, {Jun Suk} and Qiuyin Cai and Landi, {Maria Teresa} and Lee, {Kyoung Mu} and Hung, {Jen Yu} and Park, {Ju Yeon} and Margaret Tucker and Lin, {Chien Chung} and Yangwu Ren and Perng, {Reury Perng} and Chen, {Chih Yi} and Li Jin and Chen, {Kun Chieh} and Li, {Yao Jen} and Chiu, {Yu Fang} and Tsai, {Fang Yu} and Yang, {Pan Chyr} and Fraumeni, {Joseph F.} and Adeline Seow and Dongxin Lin and Baosen Zhou and Stephen Chanock and Hsiung, {Chao Agnes} and Nathaniel Rothman and Qing Lan",
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T1 - Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

AU - Hosgood, H. Dean

AU - Wang, Wen Chang

AU - Hong, Yun Chul

AU - Wang, Jiu Cun

AU - Chen, Kexin

AU - Chang, I. Shou

AU - Chen, Chien Jen

AU - Lu, Daru

AU - Yin, Zhihua

AU - Wu, Chen

AU - Zheng, Wei

AU - Qian, Biyun

AU - Park, Jae Yong

AU - Kim, Yeul Hong

AU - Chatterjee, Nilanjan

AU - Chen, Ying

AU - Chang, Gee Chen

AU - Hsiao, Chin Fu

AU - Yeager, Meredith

AU - Tsai, Ying Huang

AU - Wei, Hu

AU - Kim, Young Tae

AU - Wu, Wei

AU - Zhao, Zhenhong

AU - Chow, Wong Ho

AU - Zhu, Xiaoling

AU - Lo, Yen Li

AU - Sung, Sook Whan

AU - Chen, Kuan Yu

AU - Yuenger, Jeff

AU - Kim, Joo Hyun

AU - Huang, Liming

AU - Chen, Ying Hsiang

AU - Gao, Yu Tang

AU - Kim, Jin Hee

AU - Huang, Ming Shyan

AU - Jung, Tae Hoon

AU - Caporaso, Neil

AU - Zhao, Xueying

AU - Huan, Zhang

AU - Yu, Dianke

AU - Kim, Chang Ho

AU - Su, Wu Chou

AU - Shu, Xiao Ou

AU - Kim, In San

AU - Bassig, Bryan

AU - Chen, Yuh Min

AU - Cha, Sung Ick

AU - Tan, Wen

AU - Chen, Hongyan

AU - Yang, Tsung Ying

AU - Sung, Jae Sook

AU - Wang, Chih Liang

AU - Li, Xuelian

AU - Park, Kyong Hwa

AU - Yu, Chong Jen

AU - Ryu, Jeong Seon

AU - Xiang, Yongbing

AU - Hutchinson, Amy

AU - Kim, Jun Suk

AU - Cai, Qiuyin

AU - Landi, Maria Teresa

AU - Lee, Kyoung Mu

AU - Hung, Jen Yu

AU - Park, Ju Yeon

AU - Tucker, Margaret

AU - Lin, Chien Chung

AU - Ren, Yangwu

AU - Perng, Reury Perng

AU - Chen, Chih Yi

AU - Jin, Li

AU - Chen, Kun Chieh

AU - Li, Yao Jen

AU - Chiu, Yu Fang

AU - Tsai, Fang Yu

AU - Yang, Pan Chyr

AU - Fraumeni, Joseph F.

AU - Seow, Adeline

AU - Lin, Dongxin

AU - Zhou, Baosen

AU - Chanock, Stephen

AU - Hsiung, Chao Agnes

AU - Rothman, Nathaniel

AU - Lan, Qing

PY - 2012/7

Y1 - 2012/7

N2 - A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10 -12); however, this association did not achieve genome-wide significance (p ≠10 -7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10 -8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.

AB - A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10 -12); however, this association did not achieve genome-wide significance (p ≠10 -7) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10 -8; allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.

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