Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI

S. U. Chen, Y. R. Lien, T. M. Ko, H. N. Ho, Y. S. Yang, H. C. Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The overall incidence of chromosomal abnormalities was 8%. There was no single distinctive feature of semen parameters predictive of the existence of a chromosomal anomaly. All of the patients with obstructive azoospermia had normal karyotypes and AZF. Three patients out of 13 (23%) with nonobstructive azoospermia without 47,XXY had AZF deletions, as well as two (5%) of 43 with severe oligozoospermia. Ninety-two couples underwent 112 ICSI cycles for which a pregnancy rate of 58% was achieved. Five patients with abnormal karyotypes underwent 6 cycles of ICSI that resulted in 1 successful pregnancy. Two patients with AZF deletions achieved pregnancies. One ICSI-derived male had the same AZF deletion as his father, and 1 female baby had no risk of AZF deletion. The authors recommend karyotyping, excluding those with obstructive causes, prior to ICSI for genetic counseling.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalArchives of Andrology
Volume49
Issue number6
Publication statusPublished - Nov 1 2003
Externally publishedYes

Fingerprint

Intracytoplasmic Sperm Injections
Genetic Testing
Karyotype
Abnormal Karyotype
Oligospermia
Karyotyping
Pregnancy
Azoospermia
Genetic Counseling
Pregnancy Rate
Semen
Fathers
Chromosome Aberrations
Incidence

Keywords

  • Azoospermic factors
  • ICSI
  • Karyotype

ASJC Scopus subject areas

  • Endocrinology

Cite this

Chen, S. U., Lien, Y. R., Ko, T. M., Ho, H. N., Yang, Y. S., & Chang, H. C. (2003). Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI. Archives of Andrology, 49(6), 423-427.

Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI. / Chen, S. U.; Lien, Y. R.; Ko, T. M.; Ho, H. N.; Yang, Y. S.; Chang, H. C.

In: Archives of Andrology, Vol. 49, No. 6, 01.11.2003, p. 423-427.

Research output: Contribution to journalArticle

Chen, SU, Lien, YR, Ko, TM, Ho, HN, Yang, YS & Chang, HC 2003, 'Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI', Archives of Andrology, vol. 49, no. 6, pp. 423-427.
Chen, S. U. ; Lien, Y. R. ; Ko, T. M. ; Ho, H. N. ; Yang, Y. S. ; Chang, H. C. / Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI. In: Archives of Andrology. 2003 ; Vol. 49, No. 6. pp. 423-427.
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