Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Wei Chen Hsu, Long Shyong Lee, Cheng Chun Lee, Chang Hai Tsai, Jan Gowth Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer's disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of α 2-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and α 1-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese. Eighty-two AD patients and 110 non-affected individuals were recruited for this study. We used polymerase chain reaction (PCR) and restriction enzyme digestion to identify their genotypes. The statistical examination was performed by combining the results of our previous reports - apolipoprotein E ε4 (ApoE-4), presenilin-1 intronic polymorphism (PS-1, allele 1/2), and the five-nucleotide deletion of α 2-macroglobulin gene (A2M). Among these nine candidate genes of AD, the ApoE-4 allele is the only independent genetic risk factor for AD. The other candidate genes in this study were not associated with the occurrence of AD. In addition, there are no gene-gene interactions. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of the Neurological Sciences
Volume181
Issue number1-2
DOIs
Publication statusPublished - Dec 1 2000
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Chinese
  • Dementia
  • Genetics
  • Taiwan

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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  • Cite this

    Hu, C. J., Sung, S. M., Liu, H. C., Hsu, W. C., Lee, L. S., Lee, C. C., Tsai, C. H., & Chang, J. G. (2000). Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. Journal of the Neurological Sciences, 181(1-2), 127-131. https://doi.org/10.1016/S0022-510X(00)00443-3