Genetic polymorphisms of phase I and phase II xenobiotic enzymes in human papillomavirus related lesion and cancer of the uterine cervix

Yung Kai Huang, Hui Chen Hsieh, Jian An Sun, Chung Faye Chao, Rui Lan Huang, Hung-Cheng Lai, Tang Yuan Chu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Other than a major role of human papillomavirus (HPV) infection, exposure to cigarette smoke, estrogen and possibly other carcinogens may be related to the development of cancer. The aim of this study was to investigate whether the polymorphism of CYP1A1, CYP2E1, mEH, and GSTM1 contributes to the risk of invasive cervical cancer (ICC) and the low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix. Materials and Methods: In this study, genetic polymorphisms of xenobiotic metabolizing enzymes CYP1A1, CYP2E1, mEH, and GSTM1, as well as the status of HPV infection were determined in 113 cases with invasive cervical cancer (ICC), 80 cases of low grade squamous intraepithelial lesion (LSIL, the early lesion of HPV infection), as well as in 1:1 age-matched control subjects. Results: As expected, subjects with results positive for HPV had significant risks for LSIL and ICC, with OR (95% CI) of 19.6 (6.9-55.3) and 61.1 (25.3-147.9), respectively. In comparison with the A/A genotype, A/ G or GIG genotype of the CYP1A1 gene showed a protection for ICC, but not for LSIL, with an OR of 0.3 (95% CI of 0.1 -0.9) after adjustment with HPV status. Subjects carrying GSTM1 null genotype were at risk for LSEL (OR=2.5; 95% CI: 1.0-6.3) and ICC (OR: 2.4; 95% CI: 1.0-6.0) after HPV adjustment. The combination of CYP1A1 A/A and GSTM1 null genotype showed a higher risk for ICC (OR of 4.2, 95% CI of 1.4-12.3; p

Original languageEnglish
JournalTzu Chi Medical Journal
Volume18
Issue number4
Publication statusPublished - Aug 2006
Externally publishedYes

Fingerprint

Xenobiotics
Genetic Polymorphisms
Uterine Cervical Neoplasms
Cytochrome P-450 CYP1A1
Papillomavirus Infections
Enzymes
Genotype
Cytochrome P-450 CYP2E1
Cervix Uteri
Smoke
Tobacco Products
Carcinogens
Squamous Intraepithelial Lesions of the Cervix
Estrogens
Genes
Neoplasms

Keywords

  • Cervical cancer
  • HPV
  • Phase I and phase II xenobiotic enzymes gene polymorphism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Genetic polymorphisms of phase I and phase II xenobiotic enzymes in human papillomavirus related lesion and cancer of the uterine cervix. / Huang, Yung Kai; Hsieh, Hui Chen; Sun, Jian An; Chao, Chung Faye; Huang, Rui Lan; Lai, Hung-Cheng; Chu, Tang Yuan.

In: Tzu Chi Medical Journal, Vol. 18, No. 4, 08.2006.

Research output: Contribution to journalArticle

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abstract = "Objective: Other than a major role of human papillomavirus (HPV) infection, exposure to cigarette smoke, estrogen and possibly other carcinogens may be related to the development of cancer. The aim of this study was to investigate whether the polymorphism of CYP1A1, CYP2E1, mEH, and GSTM1 contributes to the risk of invasive cervical cancer (ICC) and the low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix. Materials and Methods: In this study, genetic polymorphisms of xenobiotic metabolizing enzymes CYP1A1, CYP2E1, mEH, and GSTM1, as well as the status of HPV infection were determined in 113 cases with invasive cervical cancer (ICC), 80 cases of low grade squamous intraepithelial lesion (LSIL, the early lesion of HPV infection), as well as in 1:1 age-matched control subjects. Results: As expected, subjects with results positive for HPV had significant risks for LSIL and ICC, with OR (95{\%} CI) of 19.6 (6.9-55.3) and 61.1 (25.3-147.9), respectively. In comparison with the A/A genotype, A/ G or GIG genotype of the CYP1A1 gene showed a protection for ICC, but not for LSIL, with an OR of 0.3 (95{\%} CI of 0.1 -0.9) after adjustment with HPV status. Subjects carrying GSTM1 null genotype were at risk for LSEL (OR=2.5; 95{\%} CI: 1.0-6.3) and ICC (OR: 2.4; 95{\%} CI: 1.0-6.0) after HPV adjustment. The combination of CYP1A1 A/A and GSTM1 null genotype showed a higher risk for ICC (OR of 4.2, 95{\%} CI of 1.4-12.3; p",
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AU - Huang, Yung Kai

AU - Hsieh, Hui Chen

AU - Sun, Jian An

AU - Chao, Chung Faye

AU - Huang, Rui Lan

AU - Lai, Hung-Cheng

AU - Chu, Tang Yuan

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AB - Objective: Other than a major role of human papillomavirus (HPV) infection, exposure to cigarette smoke, estrogen and possibly other carcinogens may be related to the development of cancer. The aim of this study was to investigate whether the polymorphism of CYP1A1, CYP2E1, mEH, and GSTM1 contributes to the risk of invasive cervical cancer (ICC) and the low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix. Materials and Methods: In this study, genetic polymorphisms of xenobiotic metabolizing enzymes CYP1A1, CYP2E1, mEH, and GSTM1, as well as the status of HPV infection were determined in 113 cases with invasive cervical cancer (ICC), 80 cases of low grade squamous intraepithelial lesion (LSIL, the early lesion of HPV infection), as well as in 1:1 age-matched control subjects. Results: As expected, subjects with results positive for HPV had significant risks for LSIL and ICC, with OR (95% CI) of 19.6 (6.9-55.3) and 61.1 (25.3-147.9), respectively. In comparison with the A/A genotype, A/ G or GIG genotype of the CYP1A1 gene showed a protection for ICC, but not for LSIL, with an OR of 0.3 (95% CI of 0.1 -0.9) after adjustment with HPV status. Subjects carrying GSTM1 null genotype were at risk for LSEL (OR=2.5; 95% CI: 1.0-6.3) and ICC (OR: 2.4; 95% CI: 1.0-6.0) after HPV adjustment. The combination of CYP1A1 A/A and GSTM1 null genotype showed a higher risk for ICC (OR of 4.2, 95% CI of 1.4-12.3; p

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