Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension

Yu Mei Hsueh, Pinpin Lin, Hui Wen Chen, Horng Sheng Shiue, Chi Jung Chung, Chiao Tzu Tsai, Yung Kay Huang, Hung Yi Chiou, Chien Jen Chen

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The association of 4 genetic polymorphisms, NAD(P)H oxidase, manganese superoxide dismutase (MnSOD), catalase, and endothelial nitric oxide synthase (e-NOS), was assessed with arsenic-related hypertension risk among 79 hypertensive cases and 213 controls in an arseniasis-hyperendemic area of Taiwan. Overall, MnSOD polymorphism significantly increased the risk of hypertension regardless of arsenic exposure. NADPH oxidase and eNOS polymorphisms were significantly associated with hypertension risk in the high arsenic exposure group; however, catalase polymorphism was not associated with hypertension. Groups were further stratified by triglyceride levels to evaluate whether the cumulative arsenic exposure combined the three polymorphisms together. The adjusted adds ratios (ORs) of at least two risk factors of the cumulative arsenic exposure and MnSOD, NADPH oxidase, and eNOS three-polymorphism combination versus any one risk factor of them were 0.8 (95% CI 0.3-2.3) for individuals with low triglyceride levels (<110 mg/dl) and 2.5 (95% CI 1.0-6.01) for high-triglyceride groups (> 110 mg/dl), respectively. These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels. Copyright

Original languageEnglish
Pages (from-to)1471-1484
Number of pages14
JournalJournal of Toxicology and Environmental Health - Part A
Volume68
Issue number17-18
DOIs
Publication statusPublished - Sep 10 2005

Fingerprint

hypertension
Arsenic
Genetic Polymorphisms
Antioxidants
Polymorphism
antioxidant
arsenic
polymorphism
Enzymes
NADPH Oxidase
enzyme
Hypertension
Superoxide Dismutase
manganese
Catalase
Triglycerides
Nitric Oxide Synthase Type III
Nitric oxide
nitric oxide
risk factor

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension. / Hsueh, Yu Mei; Lin, Pinpin; Chen, Hui Wen; Shiue, Horng Sheng; Chung, Chi Jung; Tsai, Chiao Tzu; Huang, Yung Kay; Chiou, Hung Yi; Chen, Chien Jen.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 68, No. 17-18, 10.09.2005, p. 1471-1484.

Research output: Contribution to journalArticle

Hsueh, Yu Mei ; Lin, Pinpin ; Chen, Hui Wen ; Shiue, Horng Sheng ; Chung, Chi Jung ; Tsai, Chiao Tzu ; Huang, Yung Kay ; Chiou, Hung Yi ; Chen, Chien Jen. / Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension. In: Journal of Toxicology and Environmental Health - Part A. 2005 ; Vol. 68, No. 17-18. pp. 1471-1484.
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