Genetic polymorphisms and environmental factors in the etiology of colorectal caner

Chih Ching Yeh, Ling Ling Hsieh, Fung Chang Sung

Research output: Contribution to journalArticle

Abstract

Environmental factors, including dietary and lifestyle factors, play an important role in the etiology of colorectal cancer. Advances in technology for gene analysis have generated many opportunities to elucidate genetic pathways of hereditary and sporadic colorectal cancer in the last decade. Highly penetrant mutations in certain genes, such as mismatch repair genes, play a major role in the development of hereditary colorectal cancer, while low penetrant polymorphisms play a role in metabolizing and DNA repair enzymes. Because these mutation are common, they may contribute to a large proportion of sporadic colorectal cancer. Since genetic polymorphisms may modulate an individual's response to DNA-damaging agents derived from the environment, evaluating the impact of these polymorphic genes and their interactions with environmental factors may enable us to identify susceptible subgroups and better characterize the etiology of sporadic colorectal cancer. In this review we summarize the current studies regarding the role of gene-environment interactions in the development of colorectal cancer, including genetic polymorphisms of metabolic enzymes (cytochrome P4501A1, cytochrome P4501A2, N-acetyltransferase and glutathione S-transferase) and DNA repair enzymes. We also briefly discussed areas of particular promise for further study and the limitations of these studies.

Original languageEnglish
Pages (from-to)258-278
Number of pages21
JournalTaiwan Journal of Public Health
Volume22
Issue number4
Publication statusPublished - Aug 2003
Externally publishedYes

Keywords

  • Colorectal cancer
  • Environmental factors
  • Genetic polymorphisms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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