Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families

Nobuyuki Hizawa, Linda R. Freidhoff, Eva Ehrlich, Yen Feng Chiu, David L. Duffy, Carsten Schou, Georgia M. Dunston, Terri H. Beaty, David G. Marsh, Kathleen C. Barnes, Shau Ku Huang

Research output: Contribution to journalArticle

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Abstract

Background: We have recently conducted a genome-wide screening for genes influencing Dermatophagoides pteronyssinus-specific IgE responsiveness as a part of the Collaborative Study on the Genetics of Asthma (CSGA), which showed evidence for linkage in some regions, including chromosomes 5q31-q33 and 11q13 in African American families. Objectives: To clarify relative contributions of these regions to atopy in the same African American population, we have conducted further genetic linkage studies of specific IgE responses toward common inhaled allergens. Methods: We studied 328 individuals in 58 African American families participating in the CSGA. Specific IgE responses toward Dermatophagoides farinae, cat, dog, American cockroach, rye grass, and Bermuda grass, as measured by skin tests, were used for multipoint linkage analysis with polymorphic markers on chromosomes 5q31- q33 and 11q13. Results: Specific IgE response toward American cockroach showed evidence for linkage to chromosomes 5q31-q33 (P = .0050) and 11q13 (P = .017). Specific IgE response toward dog showed evidence for linkage with chromosome 5q31-q33 (P = .0043). Evidence for linkage with chromosome 11q13 was obtained for specific IgE responses toward Dermatophagoides farinae (P = .012), cat (P = .035), and Bermuda grass (P = .017). The presence of a positive ST response for at least 1 of 30 common allergens showed evidence for linkage to chromosomes 5q31-q33 (P = .017) and 11q13 (P = .00058). Conclusions: These data support that genes on both chromosomes 5q31-q33 and 11q13 confer susceptibility to upregulated IgE-mediated immune responses in this African American population. The putative genes on chromosomes 5q31-q33 and 11q13, however, showed contrasting effects on atopy, which may result from strong gene-environmental interactions.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume102
Issue number3
DOIs
Publication statusPublished - Jan 1 1998
Externally publishedYes

Fingerprint

African Americans
Allergens
Immunoglobulin E
Chromosomes
Dermatophagoides farinae
Cynodon
Periplaneta
Genes
Cats
Asthma
Dogs
Dermatophagoides pteronyssinus
Lolium
Genetic Linkage
Skin Tests
Genetic Markers
Population
Genome

Keywords

  • Atopy
  • Chromosome 11q13
  • Chromosome 5q31-q33
  • Multipoint linkage analysts
  • Skin prick test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families. / Hizawa, Nobuyuki; Freidhoff, Linda R.; Ehrlich, Eva; Chiu, Yen Feng; Duffy, David L.; Schou, Carsten; Dunston, Georgia M.; Beaty, Terri H.; Marsh, David G.; Barnes, Kathleen C.; Huang, Shau Ku.

In: Journal of Allergy and Clinical Immunology, Vol. 102, No. 3, 01.01.1998, p. 449-453.

Research output: Contribution to journalArticle

Hizawa, Nobuyuki ; Freidhoff, Linda R. ; Ehrlich, Eva ; Chiu, Yen Feng ; Duffy, David L. ; Schou, Carsten ; Dunston, Georgia M. ; Beaty, Terri H. ; Marsh, David G. ; Barnes, Kathleen C. ; Huang, Shau Ku. / Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families. In: Journal of Allergy and Clinical Immunology. 1998 ; Vol. 102, No. 3. pp. 449-453.
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T1 - Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families

AU - Hizawa, Nobuyuki

AU - Freidhoff, Linda R.

AU - Ehrlich, Eva

AU - Chiu, Yen Feng

AU - Duffy, David L.

AU - Schou, Carsten

AU - Dunston, Georgia M.

AU - Beaty, Terri H.

AU - Marsh, David G.

AU - Barnes, Kathleen C.

AU - Huang, Shau Ku

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N2 - Background: We have recently conducted a genome-wide screening for genes influencing Dermatophagoides pteronyssinus-specific IgE responsiveness as a part of the Collaborative Study on the Genetics of Asthma (CSGA), which showed evidence for linkage in some regions, including chromosomes 5q31-q33 and 11q13 in African American families. Objectives: To clarify relative contributions of these regions to atopy in the same African American population, we have conducted further genetic linkage studies of specific IgE responses toward common inhaled allergens. Methods: We studied 328 individuals in 58 African American families participating in the CSGA. Specific IgE responses toward Dermatophagoides farinae, cat, dog, American cockroach, rye grass, and Bermuda grass, as measured by skin tests, were used for multipoint linkage analysis with polymorphic markers on chromosomes 5q31- q33 and 11q13. Results: Specific IgE response toward American cockroach showed evidence for linkage to chromosomes 5q31-q33 (P = .0050) and 11q13 (P = .017). Specific IgE response toward dog showed evidence for linkage with chromosome 5q31-q33 (P = .0043). Evidence for linkage with chromosome 11q13 was obtained for specific IgE responses toward Dermatophagoides farinae (P = .012), cat (P = .035), and Bermuda grass (P = .017). The presence of a positive ST response for at least 1 of 30 common allergens showed evidence for linkage to chromosomes 5q31-q33 (P = .017) and 11q13 (P = .00058). Conclusions: These data support that genes on both chromosomes 5q31-q33 and 11q13 confer susceptibility to upregulated IgE-mediated immune responses in this African American population. The putative genes on chromosomes 5q31-q33 and 11q13, however, showed contrasting effects on atopy, which may result from strong gene-environmental interactions.

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