Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan

Ruwen Jou, Huang Yau Chen, Chen Yuan Chiang, Ming Chih Yu, Ih Jen Su

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.

Original languageEnglish
Pages (from-to)1390-1394
Number of pages5
JournalJournal of Clinical Microbiology
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

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Multidrug-Resistant Tuberculosis
Taiwan
Mycobacterium tuberculosis
Restriction Fragment Length Polymorphisms
Alleles
Mutation
Genes
Beijing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan. / Jou, Ruwen; Chen, Huang Yau; Chiang, Chen Yuan; Yu, Ming Chih; Su, Ih Jen.

In: Journal of Clinical Microbiology, Vol. 43, No. 3, 03.2005, p. 1390-1394.

Research output: Contribution to journalArticle

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