Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan

Ruwen Jou, Huang Yau Chen, Chen Yuan Chiang, Ming Chih Yu, Ih Jen Su

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.

Original languageEnglish
Pages (from-to)1390-1394
Number of pages5
JournalJournal of Clinical Microbiology
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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