Genetic association of blaSHV-5 with transposable elements IS26 and IS5 in Klebsiella pneumoniae from Taiwan

W. L. Yu, S. C. Chen, S. W. Hung, Y. C. Chuang, J. G. Chung, I. C. Chen, L. T. Wu

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Abstract

A cloned 5248-bp EcoRI fragment from the Klebsiella pneumoniae transferable plasmid pKP53 (> 70 kb) containing blaSHV-5 was sequenced. Insertion sequences IS26 and IS5 were found downstream from blaSHV-5. The DNA sequences of the genetic environment surrounding blaSHV-5 were homologous to plasmid p1658/97 from Escherichia coli, containing a truncated recF gene and a truncated deoR gene upstream and downstream from blaSHV-5, respectively. RecF may be involved in blaSHV-5 translocation to the plasmid by RecF-dependent recombination. This novel genetic environment may be associated with the successful proliferation and/or expression of SHV-5 in K. pneumoniae strains from Taiwan.

Original languageEnglish
Pages (from-to)806-808
Number of pages3
JournalClinical Microbiology and Infection
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Keywords

  • Bla gene
  • DNA sequence
  • Insertion sequence
  • Klebsiella pneumoniae
  • RecF
  • Sequencing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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