Abstract

Vascular endothelial growth factor (VEGF) inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs), are important as anticancer treatments through curbing tumour angiogenesis and growth. VEGF inhibitors have significant cardiovascular effects. By blocking VEGF receptors, ligands, or signal pathways, VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity, and activate cardiomyocyte apoptosis. VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia. Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors. This review updates current understandings of VEGF inhibitors on cardiovascular toxicity, explores potential mechanisms, and clarifies whether genetic or ethnic factors contribute to their adverse effects.Key MessagesVEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity and activate cardiomyocyte apoptosis.VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia.Genetic and geographic studies showed that genetic polymorphisms likely play significant predictive or prognostic roles in cardiovascular toxicity associated with VEGF inhibitors.

Original languageEnglish
Pages (from-to)46-56
Number of pages11
JournalAnnals of Medicine
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2 2018

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Keywords

  • Angiogenesis inhibitors
  • antibodies
  • cardiotoxicity
  • cardiovascular system
  • ethnic groups
  • tyrosine kinase inhibitors
  • vascular endothelial growth factors

ASJC Scopus subject areas

  • Medicine(all)

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