Generation of induced pluripotent stem cell line-NTUHi001-A from a premature ovarian failure patient with Turner's syndrome mosaicism

Chen Yu Lu, Yu An Chen, Shih Han Syu, Huai En Lu, Hong Nerng Ho, Hsin Fu Chen

Research output: Contribution to journalArticle

Abstract

Turner's syndrome (TS) is one of the main causes of premature ovarian failure (POF). However, the mechanisms underlying POF are difficult to study due to the lack of suitable disease models. Herein, we have generated a human induced pluripotent stem cell (hiPSC) line derived from the peripheral blood mononuclear cells of a female patient with Turner's syndrome mosaicism via integration-free Sendai-virus system. The hiPSCs were confirmed with a 45, X karyotype and the acquisition of pluripotency. It's likely that hiPSCs can serve as a feasible cellular model for further pathophysiological studies of POF cases, especially for those originating in TS.

Original languageEnglish
Article number101422
JournalStem Cell Research
Volume37
DOIs
Publication statusPublished - May 1 2019
Externally publishedYes

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Primary Ovarian Insufficiency
Induced Pluripotent Stem Cells
Turner Syndrome
Mosaicism
Cell Line
Sendai virus
Karyotype
Blood Cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Generation of induced pluripotent stem cell line-NTUHi001-A from a premature ovarian failure patient with Turner's syndrome mosaicism. / Lu, Chen Yu; Chen, Yu An; Syu, Shih Han; Lu, Huai En; Ho, Hong Nerng; Chen, Hsin Fu.

In: Stem Cell Research, Vol. 37, 101422, 01.05.2019.

Research output: Contribution to journalArticle

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