Generation of IgM anti-platelet autoantibody in dengue patients

Chiou Feng Lin, Huan Yao Lei, Ching Chuan Liu, Hsiao Sheng Liu, Trai Ming Yeh, Shan Tair Wang, Tzu I. Yang, Fuh Chiang Sheu, Chih Feng Kuo, Yee Shin Lin

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Dengue virus infection causes a wide range of diseases from dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS). The mechanisms involved in DHF/DSS pathogenesis remain unclear. Patient sera collected from an outbreak in southern Taiwan from November 1998 to January 1999 were studied. The presence of antibodies which cross-reacted with platelets could be detected in patient sera, and the isotype of these autoantibodies was IgM. The anti-platelet IgM levels were higher in DHF/DSS than in dengue fever patient sera in disease acute phase. These autoantibodies were still detectable in convalescent stage (1-3 weeks after acute phase) and even eight to nine months after illness. The platelet binding activity was not observed in other virus-infected patient sera tested. Further investigation showed that dengue patient sera caused platelet lysis in the presence of complement. The platelet cytotoxicity induced by DHF/DSS patient sera was higher than that by dengue fever sera. Dengue patient sera also inhibited platelet aggregation which, however, appeared to be not related to DHF/DSS development.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalJournal of Medical Virology
Volume63
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Severe Dengue
Dengue
Autoantibodies
Blood Platelets
Serum
anti-IgM
Dengue Virus
Acute Disease
Virus Diseases

Keywords

  • Dengue
  • IgM autoantibody
  • Platelet aggregation
  • Platelet lysis

ASJC Scopus subject areas

  • Virology

Cite this

Generation of IgM anti-platelet autoantibody in dengue patients. / Lin, Chiou Feng; Lei, Huan Yao; Liu, Ching Chuan; Liu, Hsiao Sheng; Yeh, Trai Ming; Wang, Shan Tair; Yang, Tzu I.; Sheu, Fuh Chiang; Kuo, Chih Feng; Lin, Yee Shin.

In: Journal of Medical Virology, Vol. 63, No. 2, 2001, p. 143-149.

Research output: Contribution to journalArticle

Lin, CF, Lei, HY, Liu, CC, Liu, HS, Yeh, TM, Wang, ST, Yang, TI, Sheu, FC, Kuo, CF & Lin, YS 2001, 'Generation of IgM anti-platelet autoantibody in dengue patients', Journal of Medical Virology, vol. 63, no. 2, pp. 143-149. https://doi.org/10.1002/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L
Lin, Chiou Feng ; Lei, Huan Yao ; Liu, Ching Chuan ; Liu, Hsiao Sheng ; Yeh, Trai Ming ; Wang, Shan Tair ; Yang, Tzu I. ; Sheu, Fuh Chiang ; Kuo, Chih Feng ; Lin, Yee Shin. / Generation of IgM anti-platelet autoantibody in dengue patients. In: Journal of Medical Virology. 2001 ; Vol. 63, No. 2. pp. 143-149.
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