Gene Sequencing for Selection of Chemotherapy Drugs Combined with Stereotactic Body Radiation Therapy for Stage IV Colon Cancer: A Case Report

黃 姚儒(Yao-Ru Huang), 陳 尚文, 丁 禮莉(Lai-Lei Ting), 郭 嘉駿(Chia-Chun Kuo), 邱 仲峰

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Abstract

Gene sequencing may be a feasible means of individualizing cancer treatment. By investigating the correlation between genetic profiles and treatment outcomes of chemotherapy, it may be possible to determine effective treatment strategies according to individual genotypes in cancer patients. Despite great advances in drugs for cancer treatment, treatment outcomes may be improved by analyzing genetic markers that indicate treatment efficacy. We report the treatment for a patient with metastatic colon cancer in which gene sequencing was used for the selection of an effective chemotherapy regimen. In addition, we describe the entire course of treatment, including the combination of surgical resection for local control and radiotherapy to eradicate distant metastases. This is a pilot report of the clinical use of gene sequencing for determining a treatment regimen. Further clinical trials are needed to optimize the personalization of cancer treatment.
Original languageEnglish
Pages (from-to)65-75
Number of pages11
Journal放射治療與腫瘤學
Volume20
Issue number1
DOIs
Publication statusPublished - 2013

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Colonic Neoplasms
Radiotherapy
Drug Therapy
Pharmaceutical Preparations
Genes
Therapeutics
Neoplasms
Genetic Markers
Genotype
Clinical Trials
Neoplasm Metastasis

Keywords

  • 大腸直腸癌
  • 基因定序
  • 立體定位放射線治療
  • 化學治療
  • Colorectal carcinoma
  • Gene sequence
  • SBRT (Stereotactic Body Radiation Therapy)
  • Chemotherapy

Cite this

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title = "Gene Sequencing for Selection of Chemotherapy Drugs Combined with Stereotactic Body Radiation Therapy for Stage IV Colon Cancer: A Case Report",
abstract = "Gene sequencing may be a feasible means of individualizing cancer treatment. By investigating the correlation between genetic profiles and treatment outcomes of chemotherapy, it may be possible to determine effective treatment strategies according to individual genotypes in cancer patients. Despite great advances in drugs for cancer treatment, treatment outcomes may be improved by analyzing genetic markers that indicate treatment efficacy. We report the treatment for a patient with metastatic colon cancer in which gene sequencing was used for the selection of an effective chemotherapy regimen. In addition, we describe the entire course of treatment, including the combination of surgical resection for local control and radiotherapy to eradicate distant metastases. This is a pilot report of the clinical use of gene sequencing for determining a treatment regimen. Further clinical trials are needed to optimize the personalization of cancer treatment.",
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author = "黃, {姚儒(Yao-Ru Huang)} and 尚文 陳 and 丁, {禮莉(Lai-Lei Ting)} and 郭, {嘉駿(Chia-Chun Kuo)} and 仲峰 邱",
year = "2013",
doi = "10.6316/TRO/201320(1)65",
language = "English",
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T1 - Gene Sequencing for Selection of Chemotherapy Drugs Combined with Stereotactic Body Radiation Therapy for Stage IV Colon Cancer: A Case Report

AU - 黃, 姚儒(Yao-Ru Huang)

AU - 陳, 尚文

AU - 丁, 禮莉(Lai-Lei Ting)

AU - 郭, 嘉駿(Chia-Chun Kuo)

AU - 邱, 仲峰

PY - 2013

Y1 - 2013

N2 - Gene sequencing may be a feasible means of individualizing cancer treatment. By investigating the correlation between genetic profiles and treatment outcomes of chemotherapy, it may be possible to determine effective treatment strategies according to individual genotypes in cancer patients. Despite great advances in drugs for cancer treatment, treatment outcomes may be improved by analyzing genetic markers that indicate treatment efficacy. We report the treatment for a patient with metastatic colon cancer in which gene sequencing was used for the selection of an effective chemotherapy regimen. In addition, we describe the entire course of treatment, including the combination of surgical resection for local control and radiotherapy to eradicate distant metastases. This is a pilot report of the clinical use of gene sequencing for determining a treatment regimen. Further clinical trials are needed to optimize the personalization of cancer treatment.

AB - Gene sequencing may be a feasible means of individualizing cancer treatment. By investigating the correlation between genetic profiles and treatment outcomes of chemotherapy, it may be possible to determine effective treatment strategies according to individual genotypes in cancer patients. Despite great advances in drugs for cancer treatment, treatment outcomes may be improved by analyzing genetic markers that indicate treatment efficacy. We report the treatment for a patient with metastatic colon cancer in which gene sequencing was used for the selection of an effective chemotherapy regimen. In addition, we describe the entire course of treatment, including the combination of surgical resection for local control and radiotherapy to eradicate distant metastases. This is a pilot report of the clinical use of gene sequencing for determining a treatment regimen. Further clinical trials are needed to optimize the personalization of cancer treatment.

KW - 大腸直腸癌

KW - 基因定序

KW - 立體定位放射線治療

KW - 化學治療

KW - Colorectal carcinoma

KW - Gene sequence

KW - SBRT (Stereotactic Body Radiation Therapy)

KW - Chemotherapy

KW - Colorectal carcinoma

KW - Gene sequence

KW - SBRT (Stereotactic Body Radiation Therapy)

KW - Chemotherapy

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DO - 10.6316/TRO/201320(1)65

M3 - Article

VL - 20

SP - 65

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JO - 放射治療與腫瘤學

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