Gene Sequencing for Selection of Chemotherapy Drugs Combined with Stereotactic Body Radiation Therapy for Stage IV Colon Cancer: A Case Report

黃 姚儒(Yao-Ru Huang), 陳 尚文, 丁 禮莉(Lai-Lei Ting), 郭 嘉駿(Chia-Chun Kuo), 邱 仲峰

Research output: Contribution to journalArticle

5 Downloads (Pure)


Gene sequencing may be a feasible means of individualizing cancer treatment. By investigating the correlation between genetic profiles and treatment outcomes of chemotherapy, it may be possible to determine effective treatment strategies according to individual genotypes in cancer patients. Despite great advances in drugs for cancer treatment, treatment outcomes may be improved by analyzing genetic markers that indicate treatment efficacy. We report the treatment for a patient with metastatic colon cancer in which gene sequencing was used for the selection of an effective chemotherapy regimen. In addition, we describe the entire course of treatment, including the combination of surgical resection for local control and radiotherapy to eradicate distant metastases. This is a pilot report of the clinical use of gene sequencing for determining a treatment regimen. Further clinical trials are needed to optimize the personalization of cancer treatment.
Original languageEnglish
Pages (from-to)65-75
Number of pages11
Issue number1
Publication statusPublished - 2013



  • 大腸直腸癌
  • 基因定序
  • 立體定位放射線治療
  • 化學治療
  • Colorectal carcinoma
  • Gene sequence
  • SBRT (Stereotactic Body Radiation Therapy)
  • Chemotherapy

Cite this